PřF:Bi7140 Molecular biology of viruses - Course Information

Bi7140 Molecular biology of viruses

Extent and Intensity

2/0/0. 2 credit(s) (fasci plus compl plus > 4). Type of Completion: zk (examination).

Teacher(s)

doc. RNDr. Vladislava Růžičková, CSc. (lecturer)
Mgr. Tibor Botka, Ph.D. (lecturer)

Guaranteed by

doc. RNDr. Vladislava Růžičková, CSc.
Department of Experimental Biology – Biology Section – Faculty of Science
Contact Person: doc. RNDr. Vladislava Růžičková, CSc.
Supplier department: Department of Experimental Biology – Biology Section – Faculty of Science

Timetable

Thu 10:00–11:50 B11/306

Prerequisites

B4030 Molecular biology || B5740 Molecular biology || B6130 Molecular biology || B7940 Molecular biology || B4020 Molecular biology || Bi4010 Essential molecular biology || Bi4020 Molecular biology
1.Molecular structure reproduction a function of procaryotic and eucaryotic genome. 2. Basic methods in molecular biology 3. Molecular foundation of acquired immunity. Molecular foundation of cancerogenesis.

Course Enrolment Limitations

The course is also offered to the students of the fields other than those the course is directly associated with.
The capacity limit for the course is 90 student(s).
Current registration and enrolment status: enrolled: 0/90, only registered: 0/90, only registered with preference (fields directly associated with the programme): 0/90

fields of study / plans the course is directly associated with

there are 11 fields of study the course is directly associated with, display

Course objectives

At the end of the course students should be able to distinguish and explain principles of the molecular biology, pathology and evolution of bacterial viruses, animal and plant viruses.

Learning outcomes

Student will be able to:
- explain the main molecular biological properties of bacterial viruses;
- explain the main molecular biological properties of animal and giant viruses;
- explain the main molecular biological properties of plant viruses;
- describe the molecular basis of cellular parasitism of viruses;
- compare and highlight differences in the process of reproduction of different types of viruses;
- to analyze current scientific knowledges in the field of virology;
- write an article on the importance of viruses in medical practice;

Syllabus

• Subject Molecular biology of viruses contains theory of molecular genetics of bacterial phages and eukaryotic viruses. Morphology and structure of phages, infection and lysis of bacterial cells caused by phage virions, adsorption of phage virion to the surface of bacterial cells, synthesis of bacterial viruses in host cell, mutation and recombination of bacteriophage, lysogens and genetics of temperate phage, general characteristics of some temperate phages are included in part of procaryotic viruses. Molecular biology and genetics of vertebrate and invertebrate viruses concern the papovaviruses, adenoviruses, herpesviruses, poxviruses, parvoviruses, reoviruses, flaviviruses, picornaviruses, togaviruses, arteriviruses, rhabdoviruses, paramyxoviruses, filoviruses, orthomyxoviruses, bunyaviruses, retroviruses, hepadnaviruses. Molecular biology of retroviruses including the virus HIV and HTLV, adenoviruses, herpesviruses, influenzavirus, hepadnaviruses and oncoviruses are given in detail. Molecular biology and genetics of plant viruses is focused on the caulimoviruses, geminiviruses, bromoviruses, nepoviruses, tymoviruses, tobamoviruses, tombusviruses, luteoviruses, hordeiviruses, potexviruses etc. Characteristics of main types of plant diseases caused by viruses are explained. Molecular taxonomy, evolution of viruses, prions and viroids are also declaimed. After graduation this course, the student should be able to differentiate the molecular basis of viral vitality and evolution.1. Molecular characterisation of live noncellular systems, terms and definition explaining the nature molecular biology of viruses 2. Properties of viruses having importance in their molecular classification 3. Life cycle of viruses and the types of viral infections in host organisms, molecular mechanisms of viral persistence and latency 4. Molecular characteristic of viruses of procaryotes 5. Molecular characteristic of viruses of eucaryotes i.e. vertebrates, invertebrates, and plants. 6. Molecular characteristic of oncoviruses 7. Molecular basis of occurrence of transmissible encephalopathy (TSE) 8. Molecular diagnostics and evolution of viruses.

Literature

required literature
• Přehled literatury je dostupný u vyučujícího

recommended literature
• ROSYPAL, Stanislav. Úvod do molekulární biologie : dodatek. 2. rozš. vyd. Brno: Stanislav Rosypal, 1997, 996 s. info
• ROSYPAL, Stanislav. Úvod do molekulární biologie. Díl druhý, (Makromolekulární biologie eukaryot). 3. inovované vyd. Brno: Stanislav Rosypal, 1999, s. 304-600. ISBN 80-902562-1-X. info
• CANN, Alan J. Principles of molecular virology. London: Academic Press, 1993, 234 s. ISBN 0-12-158531-X. info
• Všeobecná virológia. Edited by Jaroslav Žemla - Fedor Čiampor - Jozef Leššo. 1. vyd. Bratislava: Slovac Academic Press, 1995, 238 s., il. ISBN 80-85665-47-6. info
• TIMBURY, Morag C. Notes on medical virology. 11th ed. New York: Churchill Livingstone, 1997, 196 s. ISBN 0-443-05846-6. info
• Špeciálna virológia. Edited by Jaroslav Žemla - Fedor Čiampor - Milan Labuda. 1. vyd. Bratislava: Slovac Academic Press, 1998, 226 s., č. ISBN 80-88908-04-3. info
• LEVY, Jay A., Heinz FRAENKEL-CONRAT and Robert A. OWENS. Virology. 3rd ed. Englewood Cliffs: Prentice-Hall, 1994, xii, 447 s. ISBN 0-13-953753-8. info

not specified
• Antti Vaheri1, et al. 2013. Uncovering the mysteries of hantavirus infections . NATURE REVIEWS | MICROBIOLOGY VOLUME 11, 539
• George P. C. Salmond and Peter C. Fineran: 2015. A century of the phage: past, present and future. NATURE REVIEWS | MICROBIOLOGY VOLUME 13, 777.
• J. Lindsay Whitton, Christopher T. Cornell and Ralph Feuer. 2005 HOST AND VIRUS DETERMINANTS OF PICORNAVIRUS PATHOGENESIS AND TROPISM. NATURE REVIEWS | MICROBIOLOGY VOLUME 3, 765.
• Jeroen De Smet, et al. 2017. Pseudomonas predators:understanding and exploiting phage–host interactions. NATURE REVIEWS | MICROBIOLOGY VOLUME 15, 517.
• Chantal Abergel et al. 2015. The rapidly expanding universe of giant viruses: Mimivirus, Pandoravirus, Pithovirus and Mollivirus. FEMS Microbiology Reviews, fuv037, 39, 779–796.
• ROHWER, Forest, Merry YOULE, Heather MAUGHAN and Nao HISAKAWA. Life in our phage world : centennial field guide to the Earth's most diverse inhabitants. Illustrated by Leah L. Pantéa - Ben Darby. First edition. San Diego: Wholon, 2014, xviii, 382. ISBN 9780990494300. info

Teaching methods

Lecture is attended by commentated PowerPoint presentations including schemes, diagrams, figures and animated illustrations concerning the topic of the lecture. Study materials are available in the IS.

Assessment methods

Lecture is finished by written examination including: test questions, making graphics with commentary and answer the single questions. Graduation of this subject depends on minimally 60% successfulness in written examination and attending on lectures.

Language of instruction

Czech

Follow-Up Courses

• Bi8312 Practical Course in Molecular Biology of Viruses

Further comments (probably available only in Czech)

Study Materials
The course can also be completed outside the examination period.
The course is taught annually.

Teacher's information

http://orion.sci.muni.cz/kgmb/Student/7140.htm

• Enrolment Statistics (Autumn 2019, recent)
  
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