BVLC011p Medical Chemistry-lecture

Faculty of Medicine
Autumn 2014
Extent and Intensity
2/0. 4 credit(s). Type of Completion: zk (examination).
Teacher(s)
doc. RNDr. Jiří Dostál, CSc. (lecturer)
prof. RNDr. Eva Táborská, CSc. (lecturer)
Mgr. Jana Kantorová (assistant)
MUDr. Michaela Králíková, Ph.D. (assistant)
RNDr. Hana Paulová, CSc. (assistant)
Mgr. Jiří Slanina, Ph.D. (assistant)
doc. RNDr. Josef Tomandl, Ph.D. (assistant)
Mgr. Marie Tomandlová, Ph.D. (assistant)
Guaranteed by
prof. RNDr. Eva Táborská, CSc.
Department of Biochemistry – Theoretical Departments – Faculty of Medicine
Supplier department: Department of Biochemistry – Theoretical Departments – Faculty of Medicine
Timetable
Mon 22. 9. to Sun 21. 12. Mon 9:30–11:20 B11/334; and Mon 15. 9. 9:30–11:20 B22/116 aula
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
Graduate in chemistry has knowledge that is necessary for understanding of chemical principles applied in further study subjects, especially in biochemistry. General chemistry provides students with understanding of solution properties and basic physico-chemical laws. Inorganic chemistry gives the overview of properties of elements and inorganic compounds important for medicine, nutrition and toxicology. Organic and bioorganic chemistry enable students to become familiar with compounds and reactions taking part in metabolism and with organic compounds that have importance in toxicology.
Syllabus
  • Information concerning medical chemistry. The basic chemical terms: substances, particles, amount of substance, some properties of a single particle and molar quantities. Electron configurations in atoms. Types of bonds, electronegativity. Non-covalent bonds and attraction forces.
  • Chemical reactions, kinetics, chemical equilibrium. The driving force of chemical reactions, free Gibbs energy.
  • Solutions of substances. Dissociation of electrolytes, the equilibria in electrolyte solutions.Precipitation reactions.
  • Protolytic reactions: acids and bases, pH values, hydrolysis of salts, buffers.
  • Oxidation-reduction reactions, redox potentials, the e.m. force of a voltaic cell and the relation to the reaction free energy change.
  • Essential macroelements important for living matter, general properties of them and of some of their compounds.
  • Carbon compounds: their constitution, configuration, isomerism, and conformation. Types of organic compounds, the principals of nomenclature. Hydrocarbons, major types, structures, reactivity.
  • Derivatives of hydrocarbons: alcohols, thioalcohols, phenols, carbonyl compounds, and carboxylic acids.
  • Substituted carboxylic acids and derivatives of the acids (esters, amides, anhydrides, halides).
  • Amines and the other derivatives of hydrocarbons.
  • Heterocyclic compounds and biochemically important derivatives. Alkaloids.
  • Structures and properties of monosaccharides. Simple sugar derivatives. Oligosaccharides, polysaccharides.
  • Heteroglycosides. Nucleosides, nucleotides, structures of nucleic acids.
  • Fatty acids and alcohols in lipids. Triacylglycerols and waxes. Phospholipids and glycolipids.
  • Icosanoids. Isoprenoids. Steroids, structures of representative compounds.
  • Standard and other alpha-amino acids, structures and common properties, polarity. Peptides, some groups of peptides exhibiting biological activity.
  • Proteins, main features of the structure of globular, fibrous, and membrane proteins. Glycoproteins. Haemoproteins, haem and other tetrapyrrols.
Literature
Teaching methods
Teaching form are lectures. Supplementary subjects are seminars and practicals (VSLC011c and VSLC011c).
Student must have course-unit credit of seminar and practicals in the day of exam.
Examination from Medical chemistry is only written. The test consists from two parts.
The first part comprises 25 questions and is solved on computers in the computer room of Department of Biochemistry (time limit 45 min): 4-5 calculations (concentration, pH, buffers, osmotic pressure) – see seminars
simple questions (multiple choice or free answer)
structural formulas (essential organic and inorganic compounds)
Each correct answer counts for 1 point, in one question is possible to obtain 3 points. The maximal acquisition = 27 points.
The second part (time limit 45 min) comprises 3x5 problems, as active answers, from the three blocks (general + inorganic chemistry, organic chemistry, bioorganic chemistry). One block contains five parts (a-e), each part a-e is donated by 2 points. Maximal acquisition = 30 points .
Answers have to be very explicit. Write very legibly, illegible answers will not be assessed.
Assessment methods
Teaching form are lectures. Supplementary subjects are seminars and practicals (VSLC011c and VSLC011c).
Student must have course-unit credit of seminar and practicals in the day of exam.
Examination from Medical chemistry is only written. The test consists from two parts. The first part is solved on computers in the computer room of Department of Biochemistry: calculations (concentration, pH, buffers, osmotic pressure) – see seminars simple questions (multiple choice or free answer) structural formulas (essential organic and inorganic compounds). The second part is written and is focused on the active knowledge of structural formulas of the most important compounds, expression of important biochemical reactions by chemical equations and the ability to formulate the basic physico-chemical relationships or to draw graphs. For detailed instructions see Study materials - Information about exam.
Language of instruction
Czech
Further comments (probably available only in Czech)
The course is taught annually.
Information on the extent and intensity of the course: celkem 30 hodin.
Listed among pre-requisites of other courses
The course is also listed under the following terms Autumn 2009, Autumn 2010, Autumn 2011, Autumn 2012, Autumn 2013, Autumn 2015, Autumn 2016, Autumn 2017, autumn 2018, autumn 2019, autumn 2020, autumn 2021, autumn 2022, autumn 2023, autumn 2024.
  • Enrolment Statistics (Autumn 2014, recent)
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