BVTO0311p Medical toxicology - lecture

Faculty of Medicine
autumn 2019
Extent and Intensity
1/0/0. 2 credit(s). Type of Completion: zk (examination).
Teacher(s)
RNDr. Ondřej Zvěřina, Ph.D. (lecturer)
RNDr. Danuše Lefnerová, Ph.D. (lecturer)
doc. RNDr. Pavel Coufalík, Ph.D. (lecturer)
Guaranteed by
RNDr. Ondřej Zvěřina, Ph.D.
Department of Public Health – Theoretical Departments – Faculty of Medicine
Contact Person: MVDr. Halina Matějová
Supplier department: Department of Public Health – Theoretical Departments – Faculty of Medicine
Timetable
Tue 7:00–8:40 A21/112
Prerequisites
BVBC0221p Biochemistry I -lect. || VSBC0221p Biochemistry I -lect. && BVEK011p Ecology
Prerequisites: biochemistry
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
On successful completion of the course student will obtain the basic knowledge about the field of general toxicology: routes of exposure (intake of chemicals); internal exposure (uptake of chemicals); metabolism; genetic polymorphism and its role in the individual vulnerability; routes of excretion. Biological effects of exposure to xenobiotics, methods of measurements and evaluation;
In the specific part of medical toxicology, student will be able to understand the role of important xenobiotics contaminated the food chains in the exposure, biological effects and prevention.
Learning outcomes
At the end of the course student is able to describe the main contaminants in the environment and mechanism of their action on human health.
Syllabus
  • Environmental chemical contaminants - problems, world catastrophes. Intake, uptake in toxicology. Anti-chemical defense systems in the human body. Metabolism of chemicals, the role of microsomal enzymes. Genetic determination of the differences in the metabolism of xenobiotics, the effects on human sussceptibility to chemicals. The methods of experimental studies in toxicology, interpretation of their results for the human exposure. Polychlorinated hydrocarbons: DDT, PCB, PCDD, PCDF: toxicology, control. Heavy metals: Hg, Pb, Cd, As, Cr: toxicology, control. Polycyclic aromatic hydrocarbons and their nitroso-derivates: toxicology, control. Pesticides, natural pesticides.
Literature
  • F.C. LU: Basic toxicology. Taylor, Francis (Ed), Washington, 1996. ISBN 1-56032-380-9
  • Ph.S.Guzelian (Ed): Similarities and differences between children and adults. ILSI Press, Washington, 1992. ISBN 0-944398-07-3
  • Manuál prevence v lékařské praxi. Edited by Kamil Provazník - Miroslav Cikrt - Lumír Komárek. Vyd. 1. Praha: Státní zdravotní ústav, 2000, 158 s. ISBN 8070711612. info
  • KOTULÁN, Jaroslav and Drahoslava HRUBÁ. Preventivní lékařství :učební text pro lékařské fakulty. Brno: Masarykova univerzita, 1993, 207 s. ISBN 80-210-0563-7. info
  • KOTULÁN, Jaroslav, Drahoslava HRUBÁ and Vladimír BENCKO. Preventivní lékařství :učební text pro lékařské fakulty. Brno: Masarykova univerzita, 1993, 285 s. ISBN 80-210-0336-7. info
Teaching methods
Lectures.
Assessment methods
Oral exam
Language of instruction
Czech
Follow-Up Courses
Further comments (probably available only in Czech)
Study Materials
Information on the extent and intensity of the course: 15.
Listed among pre-requisites of other courses
The course is also listed under the following terms Autumn 2008, Autumn 2009, Autumn 2010, Autumn 2011, Autumn 2012, Autumn 2013, Autumn 2014, Autumn 2015, Autumn 2016, Autumn 2017, autumn 2018, autumn 2020, autumn 2021, autumn 2022, autumn 2023, autumn 2024.
  • Enrolment Statistics (autumn 2019, recent)
  • Permalink: https://is.muni.cz/course/med/autumn2019/BVTO0311p