VLFA07212p Farmakologie I - přednáška

Faculty of Medicine
autumn 2020
Extent and Intensity
2/0/0. 1 credit(s). Type of Completion: k (colloquium).
Teacher(s)
doc. MUDr. Regina Demlová, Ph.D. (lecturer)
doc. PharmDr. Jan Juřica, Ph.D. (lecturer)
Mgr. Petra Amchová, Ph.D. (lecturer)
doc. RNDr. Ladislava Bartošová, Ph.D. (lecturer)
Mgr. Jana Kubátová, Ph.D. (lecturer)
doc. Mgr. MVDr. Leoš Landa, Ph.D. (lecturer)
MUDr. Alena Máchalová, Ph.D. (lecturer)
Mgr. Kristýna Nosková, Ph.D. (lecturer)
MUDr. Jana Nováková, Ph.D. (lecturer)
MUDr. Jana Pistovčáková, Ph.D. (lecturer)
doc. PharmDr. Jana Rudá, Ph.D. (lecturer)
PharmDr. Jitka Rychlíčková, Ph.D. (lecturer)
Mgr. Barbora Říhová, Ph.D. (lecturer)
PharmDr. Lenka Součková, Ph.D. (lecturer)
prof. MUDr. Dalibor Valík, Ph.D., DABCC (lecturer)
prof. RNDr. Lenka Zdražilová Dubská, Ph.D. (lecturer)
doc. PharmDr. Ondřej Zendulka, Ph.D. (lecturer)
MUDr. Róbert Balog (assistant)
Renata Bláblová (assistant)
PharmDr. Mária Hricková (assistant)
Květoslava Sedlářová (assistant)
MUDr. Filip Šiška (assistant)
PharmDr. Tomáš Hammer, Ph.D. (alternate examiner)
PharmDr. Eva Klásková (alternate examiner)
PharmDr. Katarína Kostolanská (alternate examiner)
Guaranteed by
doc. MUDr. Regina Demlová, Ph.D.
Department of Pharmacology – Theoretical Departments – Faculty of Medicine
Contact Person: Mgr. Barbora Říhová, Ph.D.
Supplier department: Department of Pharmacology – Theoretical Departments – Faculty of Medicine
Timetable
Mon 5. 10. 16:00–17:40 B11/114, Mon 12. 10. 16:00–17:40 B11/114, Mon 19. 10. 16:00–17:40 B11/114, Mon 26. 10. 16:00–17:40 B11/114, Mon 2. 11. 16:00–17:40 B11/114, Mon 9. 11. 16:00–17:40 B11/114, Mon 16. 11. 16:00–17:40 B11/114, Mon 23. 11. 16:00–17:40 B11/114, Mon 30. 11. 16:00–17:40 B11/114, Mon 7. 12. 16:00–17:40 B11/114, Mon 14. 12. 16:00–17:40 B11/114, Mon 4. 1. 16:00–17:40 B11/114, Mon 11. 1. 16:00–17:40 B11/114, Mon 18. 1. 16:00–17:40 B11/114, Mon 25. 1. 16:00–17:40 B11/114
Prerequisites (in Czech)
VLPF0622p Pathophysiol. II - lect. && VLPA0622c Pathology - practice
Course Enrolment Limitations
The course is also offered to the students of the fields other than those the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
The aims of the course are:
to explain the basic pharmacodynamic and pharmacokinetic processes and principles
to describe the factors that influence the drug effect
provide an overview of drugs affecting ANS, hormonal treatment, analgesics and anesthetics
Learning outcomes
Student after the course:
knows basic pharmacodynamic principles
knowns basic pharmacokinetic principles
knows basic factors that influence the effect of drugs
knows drugs affecting ANS, hormonal treatment, analgesics, anesthetics
Syllabus

  • VLFA07212p - Pharmacology I - Lectures

    General medicine

    Autumn semester 2020

  • 5. 10. 2020 16:00-17:40, UKB A11/114
  • PHARMACOLOGY AND ITS SUB-BRANCHES
  • Course content: Definition of pharmacology and its sub-branches of pharmacology. Drug, medical product – basic pharmacological terminology. Sources of research and development of new drugs. Principles of correct drug use – types of pharmacotherapy and rational pharmacotherapy.
  • 12. 10. 2020 16:00-17:40, UKB A11/114
  • ROUTES OF DRUG ADMINISTRATION. OVERVIEW OF DRUG DOSAGE FORMS
  • Course content: Classification of routes of administration, description of the individual ways with examples of drugs. Overview of innovative administration routes. Classification and overview of drug dosage forms for ready-made production and individual preparation, advantages and disadvantages of the particular types of drug dosage forms in clinical use, typical auxiliary substances (excipients). Drug dosage forms with controlled release.
  • 19. 10. 2020 16:00-17:40, UKB A11/114
  • DRUG LIFE-CYCLE
  • Course content: Resources, research and development of new drugs
  • 26. 10. 2020 16:00-17:40, UKB A11/114
  • PHARMACOKINETICS I
  • Course content: General principles of drug's fate in the organism. Overview of the basic pharmacokinetic processes and parameters.
  • 2. 11. 2020 16:00-17:40, UKB A11/114
  • PHARMACOKINETICS II
  • Course content: Single, continual and repeated drug administration. Principles of therapeutic drug monitoring. Compartment models. Fundamentals of population pharmacokinetics.
  • 9. 11. 2020 16:00-17:40, UKB A11/114
  • PHARMACODYNAMICS
  • Course content: Mechanisms of drugs effects – classification, examples. Receptor theory – types of ligands and receptors. Change in drug effect after repeated administration.
  • 16. 11. 2020 16:00-17:40, UKB A11/114
  • FACTORS AFFECTING DRUG'S EFFECTS
  • Course content: Classification, overview and examples of factors affecting drug effects. Fundamentals of pharmacogenomics.
  • 23. 11. 2020 16:00-17:40, UKB A11/114
  • PHARMACOVIGILANCE AND DRUG'S SAFETY
  • Course content: Adverse effects of drugs - classification and characteristics. Pharmacovigilance in clinical research and practice. Therapeutic index, therapeutic range. Drug anamnesis, polypharmacy and introduction to drug interactions.
  • 30. 11. 2020 16:00-17:40, UKB A11/114
  • PHARMACOLOGY OF AUTONOMIC NERVOUS SYSTEM
  • Course content: Overview of pharmacology of sympathetic and parasympathetic nervous system – neurotransmission, receptors. Basic indications of substances affecting ANS.
  • 7. 12. 2020 16:00-17:40, UKB A11/114
  • SPASMOLYTIC DRUGS
  • BASIC PRINCIPLES OF BIOLOGICAL THERAPY,
  • Course content: Definition of terms, advantages and disadvantages of biological treatment in comparison to conventional therapy. Fundamental principles of technologies used in production of biological medical products, their classification and examples of clinical use.
  • 14. 12. 2020 16:00-17:40, UKB A11/114
  • GENERAL AND LOCAL ANAESTHETIC AGENTS
  • Course content: Classification and pharmacological characteristics of general and local anaesthetic drugs.
  • 4. 1. 2021 16:00-17:40, UKB A11/114
  • ANALGESIC DRUGS
  • Course content: Classification of analgesic drugs. Basic pharmacological characteristics and examples of use of opioid analgesics, non-steroidal anti-inflammatory drugs and analgesic-antipyretic drugs.
  • 11. 1. 2021 16:00-17:40, UKB A11/114
  • PHARMACOTHERAPY OF DIABETES MELLITUS
  • Course content: Insulins and anti-diabetic drugs – classification and basic pharmacological characteristics.
  • 18. 1. 2021 16:00-17:40, UKB A11/114
  • PHARMACOLOGY OF SEX HORMONES
  • Course content: Analogues and antagonists FSH, LH. Oestrogens, antioestrogens, gestagens, antigestagens, androgens, antiandrogens basic pharmacological characteristics (classification, basic substances, therapeutic indications/contraindications, adverse effects).
  • 25. 1. 2021 16:00-17:40, UKB A11/114
  • GLUCOCORTICOIDS
  • IMMUNOPHARMACOLOGY - IMMUNOSUPRESSIVES AND IMMUNOMODULATORS, BIOLOGICS
  • Course content: Overview of local and systemic glucocorticoids. Drugs used in rheumatoid arthritis. Overview of drugs affecting immune system - classification, therapeutic use, basic pharmacological characteristics.
Literature
    required literature
  • RANG, H. P., James RITTER, R. J. FLOWER and Graeme HENDERSON. Rang & Dale's pharmacology. Eighth edition. [Edinburgh]: Churchill Livingstone, 2016, xv, 760. ISBN 9780702053627. info
  • http://search.ebscohost.com/login.aspx?direct=true&db=nlebk&AN=1160493&lang=cs&site=ehost-live
    recommended literature
  • Ritter J et al. Rang and Dale's pharmacology. 9th Edition. Edinburgh : Elsevier [2020]
  • Landa Leoš, Jan Juřica, Kristýna Nosková, Ondřej Zendulka: Vybrané kapitoly z obecné farmakologie pro studenty všeobecného a zubního lékařství na LF MU. Multimediální podpora výuky klinických a zdravotnických oborů :: Portál Lékařské fakulty Masarykovy
  • ŠVIHOVEC, Jan a kol. Farmakologie, Praha: Grada, 2018. ISBN 978-80-247-5558-8. www.grada.cz/farmakologie-(1)-8687
  • Markova farmakoterapie vnitřních nemocí. Edited by Josef Marek - Michal Vrablík. 5., zcela přepracované a d. Praha: Grada, 2019, xxiv, 868. ISBN 9788024750781. info
  • Základy receptury léčivých přípravků. Nováková a kol., 2010, http://portal.med.muni.cz/clanek-553-zaklady-receptury-lecivych-pripravku.html
  • Základy speciální receptury léčivých přípravků, Juřica a kol., 2014, http://portal.med.muni.cz/clanek-611-zaklady-specialni-receptury-lecivych-pripravku.html
  • Životní cyklus léčiv, Demlová a kol., 2014, http://portal.med.muni.cz/clanek-621-zivotni-cyklus-leciv-klinicke-hodnoceni-a-registrace-lecivych-pripravku-farmakovigilance-a-stanovovani-cen-a-uhrad-leciv.html
  • Soubor kazuistik z farmakologie, Zendulka a kol., 2016 http://elportal.cz/publikace/kazuistiky-farmakologie
  • Základy farmakoekonomiky, Říhová a kol, 2016, http://portal.med.muni.cz/clanek-649-zaklady-farmakoekonomiky.html
  • Atlas léčivých rostlin, https://is.muni.cz/auth/do/med/el/lecive_rostliny/atlas.html
    not specified
  • Farmakovigilance a propagace léčiv, Vršková a kol., 2007, http://portal.med.muni.cz/clanek-461-farmakovigilance-a-propagace-leciv.html
  • Výzkum nových léčiv od zrodu k registraci, Starobová a kol., 2006, http://portal.med.muni.cz/clanek-367-vyzkum-novych-leciv-od-zrodu-k-registraci.html
  • Farmakologie pro studenty bakalářských oborů na LF MU, Máchalová a kol., 2015, http://portal.med.muni.cz/clanek-644-farmakologie-pro-studenty-bakalarskych-oboru-na-lf-mu.html
  • MARTÍNKOVÁ, Jiřina. Farmakologie pro studenty zdravotnických oborů. 2., zcela přeprac. a doplň. Praha: Grada, 2014. ISBN 9788024713564. info
  • DOSTÁLEK, Miroslav, Jan JUŘICA, Eva JANOŠTÍKOVÁ and Lucia ZAHRADNÍKOVÁ. Farmakokinetika (Pharmacokinetics). ČR: Grada, 2006, 220 pp. Farmacie a farmakologie. ISBN 80-247-1464-7. info
  • WHALEN, Karen. Pharmacology. Edited by Richard Finkel - Thomas A. Panavelil. 6th ed. Philadelphia, Pa.: Lippincott Williams & Wilkins, 2015, xi, 664. ISBN 9781451191776. info
  • Waller, Derek - Renwick, Andrew G. - Hillier, Keith. Medical pharmacology and therapeutics. 3rd ed. New York : Elsevier Saunders, 2009. ix, 744 p. ISBN 0-7020-2991-2.
  • Ritter, James M. - Lewis, Lionel D. - Mant, Timothy G.K. - Ferro, Albert. A Textbook of Clinical Pharmacology and Therapeutics, 5th Ed., Hodder Arnold, 2008. 465 s. ISBN 978-0-340-90046-8
  • Pharmaceutical practice. Edited by Judith A. Rees - Ian Smith - Jennie Watson. 5th ed. Edinburgh: Churchill Livingstone Elsevier, 2014, xvii, 552. ISBN 9780702051432. info
  • Practicals in Pharmacology, 2009, Náhradní obsah: http://portal.med.muni.cz/article-491-practicals-in-pharmacology.html
Teaching methods (in Czech)
přednášky, teoretická příprava

Výuka probíhá periodicky v odpoledních hodinách. Na přednášky navazují praktická cvičení. V přednáškách je probrána základní problematika látky. Tato znalost je dále prohlubována a procvičována na konkrétních praktických úkolech ve cvičeních. Ve studijních materiálech budou ke každému tématu dle sylabů k dispozici podklady pro samostudium a přípravu, včetně odkazů na příslušné kapitoly v učebnici.

Přednášky budou probíhat online (teleprezenční výuka)
 Stream přednášek lze sledovat on-line dle rozvrhu (pondělí 5. 10. 2020 až 25. 1. 2021 v době 16:00-17:40) na předem zaslaném odkaze nebo přes odkaz ve studijních materiálech předmětu a s možností následné diskuze s vyučujícím (chat prostřednictvím MS Teams). Nahrávka kompletního videa s prezentací bude následně k dispozici ve studijních materiálech předmětu VLFA07212p.
Assessment methods
Colloquium - written ROPOT test: 40 multiple-choice questions with 3 to 5 options of asnwers. The number of correct answers is given.

Student gets 2 points for each completely correct answer, i.e. maximum 80 points for the whole multiple-choice test. Time limit: 45 min. The MCQ test can be repeated only twice.

To pass the colloquium successfully the student has to obtain at least 40 points.
Language of instruction
Czech
Further comments (probably available only in Czech)
The course is taught annually.
Information on the extent and intensity of the course: 30.
Listed among pre-requisites of other courses

Zobrazit další předměty

Teacher's information

General pharmacology:

1. Pharmacology, sub-branches, origin of drugs, drug names.

2. Types of pharmacotherapy, rules of rational and safe pharmacotherapy. The question of drug misuse.

3. Preclinical and clinical trials, stages.

4. Basic legislation related to drug use, Sources of information on drugs and medicinal products.

5. Solid and gaseous pharmaceutical drug dosage forms - overview and their influence on pharmacokinetics and pharmacodynamics.

6. Semi-solid and liquid pharmaceutical drug dosage forms - overview and their influence on pharmacokinetics and pharmacodynamics.

7. Routes of drug administration – overview, characteristics.

8. Drug absorption, presystemic elimination, drug bioavailability.

9. Drug distribution, volume of distribution, redistribution. General principles of drug movement through the body.

10. Drug elimination, processes of the first and zero order, drug accumulation.

11. Drug biotransformation – stages, examples.

12. Drug excretion (ways of excretion, possibilities of their influence).

13. Therapeutic monitoring of drugs (TDM).

14. Pharmacokinetics of single, repeated and continual drug administration.

15. Modes of drug action

16. Inhibition and induction of enzymes in pharmacokinetics and pharmacodynamics of drugs – examples.

17. Synergism and antagonism in drug effect (pharmacokinetics, pharmacodynamics).

18. Dose – response curves, types of doses, drug anamnesis, patient‘s adherence.

19. Adverse drug reactions (types, categories, examples).

20. Pharmacovigilance, drug safety.

21. Primary resistance of the patient to the treatment. Influence of repeated administration on drug efficacy - examples of tolerance and tachyphylaxis.

22. Factors influencing the drug effect – examples.

23. Pharmacotherapy in elderly, the influence of co-morbidities on drug effect, polypharmacy.

24. Pharmacotherapy in pediatric population, in breastfeeding women. Drugs influencing breast feeding.

25. Pharmacotherapy in pregnancy, drug teratogenicity.

26. Pharmacogenetics, influence of genetic polymorphisms on pharmacokinetics and pharmacodynamics of drugs.

27. Drug interactions - overview, examples.

28. Principles of biological treatment – classification, technology, examples of clinical use.

Special pharmacology:

1. Sympathomimetics - overview of single classes and their indications, examples of drugs

2. Sympatholytics - overview of single classes and their indications, examples of drugs

3. Cholinomimetics

4. Cholinolytics

5. Antispasmodics - GIT + UGT

6. Opioid analgesics

7. NSAIDs, non-opioid analgesics, antimigraine agents

8. Antiuratics, antirheumatics incl. DMARDs

9. General anesthetics

10. Local anesthetics

11. Muscle relaxants

12. Antidiabetics (except insulins)

13. Insulins

14. Sex hormones and hormones of H-P axis

15. Uterotonics and tocolytics

16. Glucocorticoids

17. Immunostimulants + immunosuppressants (except glucocorticoids)

18. Drugs used in osteoporosis, pharmacology of thyroid gland

19. Antiasthmatics, drugs used in COPD

20. Antitussives, mucoactive drugs

21. H1 antihistamines

22. Antipsychotics

23. Drugs of neurogenerative diseases (Parkinson’s disease; dementia)

24. Antidepressants - iMAO+SSRI+NDRI

25. Antidepressants - tricyclic, NASSA, MASSA, SARI, SNRI, NARI, SMS

26. Nootropics, cognitive enhancers

27. Psychotomimetics, drugs used in ADHD

28. Anticonvulsants

29. Hypnosedatives, anxiolytics

30. Principles of antibacterial therapy – overview, modes of action, resistance, MIC, MBC

31. Penicillins, carbapenems

32. Cephalosporines, monobactams

33. Lincosamides, glycopeptides, polymyxins

34. Tetracyclines + related ATBs, amphenicoles

35. Macrolides and related ATBs

36. Aminoglycosides

37. Sulphonamides, nitrofurans and nitroimidazoles

38. Quinolones, antituberculotics

39. Antimycotics

40. Dermatologics – overview of classes, drugs and effects

41. Antivirotics

42. Antiemetic drugs, prokinetics, antivertigo drugs

43. Laxatives, antidiarrhoics, drugs of infectious diarrhoeas

44. Antiulcer agents, hepatoprotectives and drugs influencing the production and excretion of bile

45. Drugs for inflammatory bowel disease

46. Alkylating cytostatics and other drugs aiming on DNA in oncology

47. Antimetabolites + hormonal therapy in oncology

48. Targeted treatment in oncology

49. Biological treatment of autoimmune diseases

50. Hypolipidemics, anti-obesity drugs

51. Antiangial agents

52. Antihypertensives – drugs targeting RAAS

53. Antihypertensives – diuretics and aldosterone antagonists

54. Antihypertensives beta blockers + central antihypertensives

55. Antihypertensives - calcium channel blockers, α1 lytics

56. Antiarrhythmics

57. Drugs used in heart failure

58. Antiplatelet agents

59. Fibrinolytics, antifibrinolytics

60. Anticoagulants

61. Antianemics, hemostatics

62. Drugs causing addiction

63. Drugs used in the treatment of addiction

64. General principles of drug poisoning, specific antidotes and their mechanisms of action

65. Drugs used in erectile dysfunction and BHP

66. Vitamins

67. Antiglaucomatics and cycloplegics

„Essential drugs“

1. adrenalin/noradrenalin

2. dobutamine

3. ephedrine/pseudoephedrine

4. phenylephrine

5. oxymetazoline

6. methyldopa

7. salbutamol

8. doxazosin

9. metoprolol

10. timolol

11. atropine

12. butylscopolamine

13. fenpiverine/pitofenone

14. pilocarpine

15. rivastigmine

16. physostigmine

17. solifenacin

18. paracetamol/ASA

19. ibuprofen/diclofenac

20. indomethacin

21. nimesulide/meloxicam

22. buprenorphine

23. morphine/naloxone

24. sufentanil

25. tramadol

26. metamizole

27. allopurinol

28. sumatriptan

29. desflurane

30. propofol

31. ketamine

32. procaine/lidocaine

33. suxamethonium

34. prilocaine

35. metformin

36. glimepiride

37. sitagliptin

38. insulin lispro

39. insulin glargine

40. ethinylestradiol

41. cyproterone

42. tibolone

43. tamoxifen

44. hexoprenaline

45. oxytocin

46. levonorgestrel

47. dexamethasone

48. prednisone

49. cyclosporine

50. interferons

51. methotrexate

52. ibandronic acid

53. acetylcysteine

54. codeine

55. butamirate

56. ipratropium-bromide

57. bisulepine/cetirizine

58. haloperidol

59. olanzapine

60. aripiprazole

61. levodopa/carbidopa

62. metoclopramide

63. escitalopram

64. amitriptyline

65. mirtazapine

66. lithium

67. methylphenidate

68. piracetam/pyritinol

69. diazepam

70. buspirone

71. gabapentin/pregabalin

72. carbamazepine

73. valproic acid

74. zolpidem

75. midazolam

76. phenoxymethylpenicillin

77. co-amoxicillin

78. piperacillin

79. cefuroxime

80. meropenem

81. vancomycin

82. doxycycline

83. clarithromycin

84. azithromycin

85. gentamicin

86. cotrimoxazole

87. ciprofloxacin

88. rifampicin

89. terbinafine

90. caspofungin

91. amphotericin B

92. fluconazole

93. acyclovir

94. zidovudine

95. isotretinoin

96. salicylic acid

97. ondansetron

98. moxastine

99. pantoprazole

100. famotidine

101. lactulose

102. aprepitant

103. loperamide

104. betahistine

105. cinnarizine

106. cyclophosphamide

107. methotrexate

108. 5-fluorouracil

109. paclitaxel

110. doxorubicin

111. cisplatin

112. trastuzumab

113. imatinib

114. interferon alfa

115. nivolumab

116. atorvastatin

117. fenofibrate

118. ezetimibe

119. isosorbid dinitrate/nitroglycerin

120. hydrochlorothiazide/indapamide

121. furosemide

122. spironolactone

123. amlodipine

124. perindopril

125. telmisartan

126. digoxin

127. amiodarone

128. verapamil

129. levosimendan

130. warfarin

131. enoxaparin

132. clopidogrel

133. dabigatran

134. rivaroxaban

135. alteplase

136. methadone

137. buprenorphine

138. nalmefene

139. naltrexone

140. finasteride

141. sildenafil

The course is also listed under the following terms Autumn 2017, autumn 2018, autumn 2019, autumn 2021, autumn 2022, autumn 2023, autumn 2024.
  • Enrolment Statistics (autumn 2020, recent)
  • Permalink: https://is.muni.cz/course/med/autumn2020/VLFA07212p