F1SU1_13 Physical Chemistry

Faculty of Pharmacy
Spring 2025
Extent and Intensity
2/2/0. 6 credit(s). Type of Completion: zk (examination).
In-person direct teaching
Teacher(s)
doc. Mgr. Jan Muselík, Ph.D. (lecturer)
prof. PharmDr. Mgr. David Vetchý, Ph.D. (lecturer)
Mgr. Sylvie Pavloková, Ph.D. (seminar tutor)
PharmDr. Jiří Zeman, Ph.D. (seminar tutor)
Guaranteed by
prof. PharmDr. Mgr. David Vetchý, Ph.D.
Department of Pharmaceutical Technology – Departments – Faculty of Pharmacy
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.

The capacity limit for the course is 175 student(s).
Current registration and enrolment status: enrolled: 0/175, only registered: 0/175
fields of study / plans the course is directly associated with
Course objectives
The aim of the course is to make students familiar with basic knowledge of the physical chemistry, which constitutes part of the theoretical basis, necessary for understanding of processes delivered within disciplines in further stages of the study. Lectures are divided according to basic part of physical and colloid chemistry such as thermodynamics, kinetics of chemical reactions, behaviour of solutions, electrochemistry, phase equilibria, behaviour of phase interfaces, rheology, and colloidal systems. In laboratory exercises, students will learn the experimental techniques of physical chemistry. In seminars, students will get acquainted with physicochemical calculations, which are integral part of the knowledge required in the discipline.
Learning outcomes
After completing the course, the student will be able to:
– describe the thermodynamic nature of a number of pharmaceutical processes;
– describe the factors that influence the solubility and dissolution of substances;
– determine and describe kinetic parameters in pharmaceutical processes;
– identify and summarize important features of electrochemical and phase phenomena;
– apply rheological principles to a practical problem;
– identify and summarize important characteristics of colloidal systems.
Syllabus
  • LECTURES:
  • Thermodynamics.
  • Solubility: solubility gas/liquid, liquid/liquid, solid/liquid, solubility of salts, poor soluble electrolytes, weak electrolytes and their salts.
  • Electrochemistry.
  • Phase equilibria.
  • Phase interfaces.
  • Diffusion, dissolution and their importance in drug development.
  • Kinetics: rates and orders of reactions. Influence of temperature and other factors on reaction rates. The importance of kinetics in formulation and development of pharmaceuticals.
  • Rheology: Newtonian systems, non-Newtonian systems, thixotropy, determination of rheologic properties, viscoelasticity, application in pharmacy.
  • Colloids.

  • SEMINARS:
  • States of matter and thermodynamics – calculations.
  • Phase equilibria, chemical kinetics and electrochemistry – calculations.
  • Written test – calculations.

  • LABORATORY EXERCISES:
  • Density determination by pycnometric method.
  • Partitioning of succinic acid in the system butanol-water.
  • Determination of upper critical dissolution temperature of the mixture phenol-water.
  • Writtent test – theory from laboratory exercises.
Literature
    recommended literature
  • Atkins, P.W. Physical Chemistry. Oxford Univ.Press, Oxford, 1997. info
  • Kišová, L. , Trnková, L. Příklady z fyzikální chemie. PřF MU Brno, 1993. info
  • Fischer, O. a kol. Fyzikální chemie. SPN Praha, 1983. info
  • Vodrážka, Z. Fyzikální chemie pro biologické vědy. Academia, Praha, 1983. info
  • Moore, W.J. Fyzikální chemie. SNTL, Praha, 1979. info
  • Brdička, R., Dvořák, J. Základy fyzikální chemie. Academia, 1977. info
Teaching methods
lectures, seminars, laboratory exercises
Assessment methods
2 written tests (1 test for calculations from seminars and 1 test for theory from laboratory exercises; to participate in exam, you need to get at least 60 % of points from each test), written exam
Language of instruction
Czech
Further comments (probably available only in Czech)
Study Materials
The course can also be completed outside the examination period.
Teacher's information
Conditions of participation in the exam:

Participate in seminars and laboratory exercises in the full range given by the syllabus, properly write protocols from laboratory exercises. Demonstrate ongoing knowledge during seminars and laboratory exercises. Successfully pass a written test on calculations and a written test on the knowledge acquired in the laboratory exercises (min. 60 % of points). If any of the above conditions are not met, the student cannot participate in the final exam.

The course is also listed under the following terms Spring 2020, Spring 2021, Spring 2022, Spring 2023, Spring 2024.
  • Enrolment Statistics (Spring 2025, recent)
  • Permalink: https://is.muni.cz/course/pharm/spring2025/F1SU1_13