Bi9260 Cellular and molecular neurobiology

Faculty of Science
Autumn 2023
Extent and Intensity
2/0/0. 2 credit(s) (fasci plus compl plus > 4). Type of Completion: zk (examination).
Teacher(s)
prof. Mgr. Petr Beneš, Ph.D. (lecturer)
Guaranteed by
prof. Mgr. Petr Beneš, Ph.D.
Department of Experimental Biology – Biology Section – Faculty of Science
Contact Person: prof. Mgr. Petr Beneš, Ph.D.
Supplier department: Department of Experimental Biology – Biology Section – Faculty of Science
Timetable
Mon 10:00–11:50 B11/333
Prerequisites
Bi4020 Molecular biology
Principal knowledge of physiology, cell and molecular biology with focus on eukaryotic organisms.
Course Enrolment Limitations
The course is also offered to the students of the fields other than those the course is directly associated with.
fields of study / plans the course is directly associated with
there are 6 fields of study the course is directly associated with, display
Course objectives
The aim of this lecture is to make students familiar with basic principles of nervous system function at the molecular and cellular level and to try to use this knowledge to understand the function of nervous system in the whole organism.
Learning outcomes
At the end of this course students will understand essential principles of nervous system organisation, development and function. Students will be able to define key molecular mechanisms important for nervous system function.
Syllabus
  • 1. Use of model organisms for functional and developmental studies of nervous system (Drosophila, Xenopus, Aplysia, C. elegans, Mus musculus, tissue culture). 2. Neurons and neuroglial cells - morphology, function, mutual interaction. 3. Neuron signals - electrical activity, excitability, ion channels, synapses, neurotransmitters, neuromodulators, neuropeptides. 4. Cell signaling in nervous system - G-protein coupled receptors, cAMP, calcium signaling, protein phosphorylation and dephosphorylation. 5. Nervous system development, neurogenesis, neural stem cells, differentiation of neurons and glia, specific regulation of gene expression. 6. Brain development - homeotic genes, axon growth, axon pathfinding, synapsis formation. 7. Neuronal plasticity, synaptic plasticity, neuronal adaptation. 8. Biological basis of behaviour, biological clocks, emotion, pain, stress. 9. Sensory system, learning, memory. 10. Aging and death of neurons, neuronal regeneration, neuronal diseases, neuropharmacology.
Literature
  • G. F. Striedter. Neurobiology A Functional Approach. Oxford University Press; 1 edition. 2015. 648 p. ISBN 978-0195396157
  • Genetic dissection of neural circuits and behavior. Edited by S. F. Goodwin. Elsevier Inc., 2009, 199 p, ISBN 978-0-12-374836-2
  • G. L. Fain. Molecular and Cellular Physiology of Neurons, Second Edition. Harvard University Press, 752 p. 2014. ISBN 9780674599215
  • The neurobiology of learning and memory. Edited by J. W. Rudy. Sinauer Associates, 2008, 380 p. ISBN 978-0-87893-669-4
  • SANES, Dan Harvey, Thomas A. REH and William H. HARRIS. Development of the nervous system. 3rd ed. Amsterdam: Elsevier, 2012, xvi, 341. ISBN 9780123745392. info
  • Molecular biology of the neuron. Edited by R. Wayne Davies - B. J. Morris. 2nd ed. Oxford: Oxford University Press, 2006, xvii, 480. ISBN 0198509979. info
Teaching methods
lectures, class discussion
Assessment methods
Type of examination: written test which consists of 30 questions, 50% of correct answers is needed to pass.
Language of instruction
Czech
Further Comments
Study Materials
The course is taught annually.
The course is also listed under the following terms Spring 2011 - only for the accreditation, Spring 2009, Spring 2010, Spring 2011, Spring 2012, spring 2012 - acreditation, Spring 2013, Spring 2014, Spring 2015, Autumn 2016, autumn 2017, Autumn 2018, Autumn 2019, Autumn 2020, autumn 2021, Autumn 2022, Autumn 2024.
  • Enrolment Statistics (Autumn 2023, recent)
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