VSBC041p Biochemistry II - lecture

Faculty of Medicine
Spring 2013
Extent and Intensity
1/0/0. 3 credit(s). Type of Completion: zk (examination).
Teacher(s)
doc. RNDr. Jiří Dostál, CSc. (lecturer)
prof. MUDr. Vladimír Palyza, CSc. (lecturer)
RNDr. Hana Paulová, CSc. (lecturer)
Mgr. Jiří Slanina, Ph.D. (lecturer)
prof. RNDr. Eva Táborská, CSc. (lecturer)
doc. RNDr. Josef Tomandl, Ph.D. (lecturer)
PharmDr. Lenka Adámková, Ph.D. (assistant)
RNDr. Hana Bochořáková (assistant)
Ing. Martina Čarnecká, Ph.D. (assistant)
MUDr. Miroslava Hlaváčová, Ph.D. (assistant)
Mgr. Jana Kantorová (assistant)
MUDr. Michaela Králíková, Ph.D. (assistant)
Mgr. Milena Matejovičová, Ph.D. (assistant)
Ing. Jitka Melounová, Ph.D. (assistant)
Lenka Nerudová (assistant)
Ing. Jana Simonová, Ph.D. (assistant)
PharmDr. Kristýna Šebrlová, Ph.D. (assistant)
Mgr. Marie Tomandlová, Ph.D. (assistant)
Guaranteed by
prof. RNDr. Eva Táborská, CSc.
Department of Biochemistry – Theoretical Departments – Faculty of Medicine
Supplier department: Department of Biochemistry – Theoretical Departments – Faculty of Medicine
Timetable
Tue 7:30–8:20 B22/116 aula
  • Timetable of Seminar Groups:
VSBC041p/VLA: Tue 13:00–13:50 B22/116 aula
Prerequisites (in Czech)
VSLC011p Med. Chem. lecture && VSBI0222p Biology II-lect. && ( VSBF011p Biophysics || VLBF011p Biophysics-lect. || STBF011p Biophysics ) && VSBC0221s Biochemistry I sem && VSFY0321c Physiology I - practice && VSFY0321s Physiology I - seminar
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
The course extends the knowledge of biochemistry acquired in the course Biochemistry I and deals with integration of biochemical processes in human body.Upon completion of this course the student should understand: biochemical processes characteristic for individual organs and tissues and principles of their regulation, metabolic interrelationships between metabolism of nutrients under various conditions in organism, principles of maintenance of homeostasis and acid-base equilibrium in the body. He should also recognize which aspects of the biochemical pathways, when altered, lead to diseases.
Syllabus
  • Digestion and absorption of lipids. Blood plasma lipids and the major groups of lipoproteins. Metabolic fate of chylomicrons and VLDL, the metabolism of HDL. The biosynthesis of steroid hormones. The synthesis and hydroxylation of calciol. The integration of intermediary metabolism at the tissue and organ level. The metabolic functions of the liver. Catabolism of haemoglobin, bilirubin metabolism. Metabolism of iron. Biotransformation of xenobiotics. Control of metabolism. Mechanism of hormone and neurotransmitter action. Types of cell membrane receptors, intracellular effects of ligand binding; intracellular receptors. Nerve cells. Neurosecretion. The biosynthesis and inactivation of neurotransmitters, neurotransmission across synapses. Cholinergic, adrenergic, and (inhibitory) gabaergic receptors. Body water, the movement of water between ECF and ICF, water excretion. Ionic composition of blood plasma, gradients of Na+ and K+ across cell membranes. Osmolality of ECF, regulation of the ECF osmolality and volume, fluid and electrolyte balance. Transport of O2 and CO2. Metabolic pathways producing/consumpting H+ ions. Buffer bases of blood, blood plasma (concentrations of components), ICF, the parameters of acid-base status. The role of the lung, the kidney, and the liver in maintaining acid-base balance. Normal renal functions. Glomerular filtration. Tubular resorption and secretion. The major proteins of blood plasma. The blood-coagulation cascade, inhibition of clotting. Fibrinogen, fibrin, fibrinolysis. Blood cells. The specific immune response. Soluble and cell free antigens, immunoglobulin structures. Circulating immune complexes, secondary reactions. The extracellular matrix. Synthesis and post-translational modifications of collagen, intermolecular crosslinks in collagen and elastin, proteoglycans. Calcification of bone, regulation. Biochemical markers of bone resorption and formation.
Literature
    required literature
  • LEDVINA, Miroslav, Alena STOKLASOVÁ and Jaroslav CERMAN. Biochemie pro studující medicíny, I. a II. díl. Druhé vydání. Praha: Karolinum, 2009, 546 pp. ISBN 978-80-246-1414-4. info
  • MURRAY, Robert K., David A. BENDER, Kathleen M. BOTHAM, Peter J. KENNELLY, Victor W. RODWELL and P. Anthony WEIL. Harper's Illustrated Biochemistry. 28th ed. McGraw-Hill, 2009. ISBN 978-0-07-163827-2. info
    recommended literature
  • KOOLMAN, Jan and Klaus-Heinrich RÖHM. Barevný atlas biochemie. Grada. Praha, 2012, 498 pp. ISBN 978-80-247-2977-0. info
  • HOLEČEK, Milan. Regulace metabolizmu cukrů, tuků, bílkovin a aminokyselin. 1st ed. Praha: Grada Publishing, 2006, 286 pp. učebnice. ISBN 80-247-1562-7. info
  • CHAMPE, P. C., R. A. HARVEY and D. R. FERRIER. Lippincott's Illustrated Reviews: Biochemistry. 3rd ed. Philadelphia: Lippincott Williams & Wilkins, 2005, 534 pp. textbook. ISBN 0-7817-2265-9. info
  • KOOLMAN, Jan and Klaus-Heinrich ROEHM. Color Atlas of Biochemistry. 3rd ed. Georg Thieme Verlag, 2013. ISBN 978-3-13-100373-7. info
Teaching methods
Teaching form are lectures. Supplementary subjects are seminars and practicals (VSBC041c and VSLC041c).
Assessment methods
Student must have course-unit credit of seminar and practicals in the day of exam.
The examination has writen and oral part.The test consists of 25 questions and is solved on computers in the computer room of Department of Biochemistry (time limit 45 min) (specific personal number /UCO/ and key-word for IS MUNI is necessary for entrance to the test): As a rule, 10 questions are bent on the knowledge acquired in the practical exercises. Remaining 15 questions are bent on an essential knowledge ranging over all studied topics. Only those students who gain 14 correct answers at a minimum will be permitted to sit for the oral examination. The oral part of examination Students select three questions from the sets (1-28, 29-58, 59-89) and have about 30 minutes for the written preparation. They should summarize their answers as concisely and accurately as possible. It is recommended to follow these items: - to write a brief synopsis emphasizing the main ideas - to draw metabolic pathways in structural formulas with a short comment - where appropriate, to draw a picture A good and concise preparation reflects the students’ knowledge and understanding the biochemistry and will be considered in the final classification.
Language of instruction
Czech
Further comments (probably available only in Czech)
Study Materials
The course is taught annually.
Information on course enrolment limitations: Přihlášení ke zkoušce je podmíněno vykonáním zkoušky z Biochemie I.
Listed among pre-requisites of other courses
Teacher's information
http://www.med.muni.cz/toCP1250.cs/biochem/vyuka.html
The course is also listed under the following terms Spring 2003, Spring 2004, Spring 2005, Spring 2006, Spring 2007, Spring 2008, Spring 2009, Spring 2010, Spring 2011, Spring 2012, Spring 2014, Spring 2015, Spring 2016, Spring 2017.
  • Enrolment Statistics (Spring 2013, recent)
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