C3210 Structural bioinformatics

Faculty of Science
Autumn 2012
Extent and Intensity
1/0/0. 1 credit(s) (plus extra credits for completion). Type of Completion: zk (examination).
Teacher(s)
prof. RNDr. Jaroslav Koča, DrSc. (lecturer)
Mgr. Martin Prokop, Ph.D. (lecturer)
Guaranteed by
prof. RNDr. Jaroslav Koča, DrSc.
National Centre for Biomolecular Research – Faculty of Science
Supplier department: National Centre for Biomolecular Research – Faculty of Science
Timetable
Thu 16:00–16:50 C04/118, Thu 16:00–16:50 C04/211
Course Enrolment Limitations
The course is also offered to the students of the fields other than those the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
At the end of the course students should have basic knowledge in structural bioinformatics. The first question solved is the difference between the information included explicitly and implicitly in genome. Then 3-D reprezentation of molecules in computers is discussed. Notions of basic structural motives in proteins and nucleic acids follow. Then, possibilities of 3-D structure prediction are introduced together with implications of 3-D structure in biological functions and in designing biologically active molecules.
Syllabus
  • 1.What is structural bioinformatics ? 2.How to obtain 3-D structure ? 3.Basic structural motives in proteins, protein structure. 4.Basic structural motives in nucleic acids. Nucleic acids structure. 5.Energy as a key to predisct 3-D structure. 6.Molecular mechanics. 7.Conformational analysis. 8.How to organize 3-D data in databases. 9.Homology modeling and „threading“ 10.Molecular complexes, docking. 11.Structural bioinformatics and biologically active compounds design. 12.Drug design based on receptor and pharmacophore.
Literature
  • Structural bioinformatics. Edited by Philip E. Bourne - Helge Weissig. Hoboken, N.J.: Wiley-Liss, 2003, xix, 649. ISBN 0471201995. info
Teaching methods
Theoretical lecture.
Assessment methods
Written tests, oral examination.
Language of instruction
Czech
Further Comments
Study Materials
The course is taught annually.
The course is also listed under the following terms Autumn 2007 - for the purpose of the accreditation, Autumn 2010 - only for the accreditation, Autumn 2008, Autumn 2009, Autumn 2010, Autumn 2011, Autumn 2011 - acreditation, Autumn 2013, Autumn 2014, Autumn 2015, Autumn 2016, autumn 2017, Autumn 2018, Autumn 2019, Autumn 2020, autumn 2021, Autumn 2022, Autumn 2023, Autumn 2024.
  • Enrolment Statistics (Autumn 2012, recent)
  • Permalink: https://is.muni.cz/course/sci/autumn2012/C3210