PřF:C3210 Structural bioinformatics - Course Information
C3210 Structural bioinformatics
Faculty of ScienceAutumn 2013
- Extent and Intensity
- 1/0/0. 1 credit(s) (plus extra credits for completion). Type of Completion: zk (examination).
- Teacher(s)
- prof. RNDr. Jaroslav Koča, DrSc. (lecturer)
Mgr. Martin Prokop, Ph.D. (lecturer)
Mgr. Ing. Crina-Maria Ionescu, Ph.D. (assistant)
Sushil Kumar Mishra, Ph.D. (assistant) - Guaranteed by
- prof. RNDr. Jaroslav Koča, DrSc.
National Centre for Biomolecular Research – Faculty of Science
Supplier department: National Centre for Biomolecular Research – Faculty of Science - Timetable
- Thu 16:00–16:50 C04/211
- Course Enrolment Limitations
- The course is also offered to the students of the fields other than those the course is directly associated with.
- fields of study / plans the course is directly associated with
- Chemoinformatics and Bioinformatics (programme PřF, B-BCH)
- Course objectives
- On successful completion of the course, a learner will be able to: describe basic structural motives in proteins and nucleic acids; describe theoretical principles of methods for 3D structure prediction of proteins; interpret relationship between 3D structure and biological function; illustrate practical applicability of the principles for design of biologically active molecules.
- Syllabus
- 1.What is structural bioinformatics ? 2.How to obtain 3-D structure? 3.Basic structural motives in proteins, protein structure. 4.Basic structural motives in nucleic acids. Nucleic acids structure. 5.Energy as a key to predict 3-D structure. 6.Molecular mechanics. 7.Conformational analysis. 8.How to organize 3-D data in databases. 9.Homology modeling and „threading“ 10.Molecular complexes, docking. 11.Structural bioinformatics and biologically active compounds design. 12.Drug design based on receptor and pharmacophore.
- Literature
- Structural bioinformatics. Edited by Philip E. Bourne - Helge Weissig. Hoboken, N.J.: Wiley-Liss, 2003, xix, 649. ISBN 0471201995. info
- Teaching methods
- Theoretical lecture.
- Assessment methods
- Written test and oral examination. The test consists of 30 questions, 20 correct answers is needed to pass.
- Language of instruction
- Czech
- Further Comments
- Study Materials
The course is taught annually.
- Enrolment Statistics (Autumn 2013, recent)
- Permalink: https://is.muni.cz/course/sci/autumn2013/C3210