LF:ZLIM051p Immunology in Dent. - lecture - Course Information
ZLIM051p Immunology in Dentistry - lecture
Faculty of MedicineAutumn 2017
- Extent and Intensity
- 1/0/0. 2 credit(s). Type of Completion: zk (examination).
- Teacher(s)
- prof. MUDr. Vojtěch Thon, Ph.D. (lecturer)
prof. MUDr. Jindřich Lokaj, CSc. (lecturer)
Miroslava Bučková (assistant) - Guaranteed by
- prof. MUDr. Vojtěch Thon, Ph.D.
Department of Clinical Immunology and Allergology – Institutions shared with St. Anne's Faculty Hospital – Faculty of Medicine
Contact Person: prof. MUDr. Vojtěch Thon, Ph.D.
Supplier department: Department of Clinical Immunology and Allergology – Institutions shared with St. Anne's Faculty Hospital – Faculty of Medicine - Timetable
- Mon 6. 11. to Fri 22. 12. Tue 13:20–15:00 I.CHK N01001
- Prerequisites (in Czech)
- ZLBC0221p Biochemistry I - lecture && ZLFY0422c Physiology II - practice && ZLFY0422s Physiology II - seminar && ZLLM0421c Med.Oral Microbiol.I-pract. && ZC041 Handling chemical substances
- Course Enrolment Limitations
- The course is only offered to the students of the study fields the course is directly associated with.
- fields of study / plans the course is directly associated with
- Dentistry (eng.) (programme LF, M-ZL)
- Dentistry (programme LF, M-ZL)
- Course objectives
- The course is focused to clinical and laboratory aspects of immunology in medicine. After finishing this course the student will understand the pathogenesis of immunopathological diseases and know the clinical manifestation and the treatment approaches to the most severe disturbances of the immune system particularly focused on the orofacial localization.
- Learning outcomes
- The student will understand basic mechanisms of functioning of the immune system both in the component of innate and adaptive immunity. The student will understand the importance of the immune system in the defense against infectious agents. The student will be familiar with the compartmentalization of the immune system with an emphasis on the mucosal immune system. The student will be acquainted with the most important mechanisms leading to immunopathological diseases.
- Syllabus
- Significance of the past history and of basic clinical and laboratory investigations for indication of immunological tests. Blood count. Serum proteins. Laboratory markers of inflammation. Blood collection. Diagnostic antisera. Monoclonal antibodies as diagnostic and therapeutic tools. Interaction between antigen and antibody in vitro. Primary and secondary immunological interactions. Serological reactions - overview. Specificity and sensitivity. Titration of serum. Major histocompatibility complex: structure, function. HLA typing. Molecular genetic in immunology. Innate or natural immunity: phagocytosis, NK cells, cytotoxicity, interferon system, complement system, acute phase reaction, inflammation. Complement system evaluation. Cells of the immune system. CD nomenclature of leukocyte antigens. Phenotyping of lymphocytes. Flow cytometry. Evaluation of phagocytic cells. B lymphocytes and immunoglobulins. Biological properties of antibodies. Primary and secondary immunodeficiency disorders. HIV infection and AIDS. Active and passive immunisation. Immunoglobulin therapy. Immunostimulation. Autoimmunity and disease. Immunological tolerance. Autoantibodies and their laboratory detection. Clinically significant organ specific and organ non-specific autoantibodies. Hypersensitivity reactions - anaphylactic, cytotoxic, immune complex, T-cell-mediated. Clinical allergology. Allergic skin and exposition tests. Skin tests for early hypersensitivity. Delayed-type hypersensitivity tests. Anergy. Prevention and treatment of allergic diseases. Anaphylactic shock. Tumor immunology. Tumor antigens. Transfusion immunology. ABO system. Rh system. Transfusion reactions. Immunology of organ and bone marrow transplantation. Graft vs. host reaction.
- Literature
- recommended literature
- LITZMAN, Jiří, Zita CHOVANCOVÁ, Vojtěch THON, Marcela VLKOVÁ, Vlastimil KRÁL and Tomáš FREIBERGER. Základy vyšetření v klinické imunologii (Investigations in clinical immunology). 2., přepr. vyd. Brno: Masarykova univerzita, 2015, 71 pp. ISBN 978-80-210-7853-6. info
- HOŘEJŠÍ, Václav, Jiřina BARTŮŇKOVÁ, Tomáš BRDIČKA and Radek ŠPÍŠEK. Základy imunologie. 6., aktualizované vydání. V Praze: Stanislav Juhaňák - Triton, 2017, 297 stran. ISBN 9788075532503. info
- not specified
- CHAPEL, Helen, Mansel HAENEY, Siraj A. MISBAH and Neil SNOWDEN. Základy klinické imunologie : 6. vydání. Translated by Vojtěch Thon. Kroměříž: Triton, 2018, xiv, 343. ISBN 9788075533968. info
- Teaching methods
- Lecture. To get the creditactive participation in discussions is required. The knowledge is continuously checked by oral questions.
- Assessment methods
- Credit. To get the credit active presence on seminars is required.
- Language of instruction
- Czech
- Further comments (probably available only in Czech)
- The course is taught annually.
- Listed among pre-requisites of other courses
- Enrolment Statistics (Autumn 2017, recent)
- Permalink: https://is.muni.cz/course/med/autumn2017/ZLIM051p