aVLBC0321s Biochemie I - seminář

Lékařská fakulta
podzim 2022
Rozsah
0/4/0. 60. 7 kr. Ukončení: z.
Vyučující
doc. RNDr. Jiří Dostál, CSc. (cvičící)
RNDr. Hana Paulová, CSc. (cvičící)
Mgr. Jiří Slanina, Ph.D. (cvičící)
prof. RNDr. Eva Táborská, CSc. (cvičící)
doc. RNDr. Josef Tomandl, Ph.D. (cvičící)
MUDr. Michaela Králíková, Ph.D. (pomocník)
Bc. Ivana Ševčíková (pomocník)
Mgr. Marie Tomandlová, Ph.D. (pomocník)
Garance
doc. RNDr. Josef Tomandl, Ph.D.
Biochemický ústav – Teoretická pracoviště – Lékařská fakulta
Dodavatelské pracoviště: Biochemický ústav – Teoretická pracoviště – Lékařská fakulta
Rozvrh seminárních/paralelních skupin
aVLBC0321s/30: Po 16:00–17:40 A16/213, Čt 17:00–18:40 A16/215, J. Dostál, J. Slanina
aVLBC0321s/31: Út 10:00–11:40 A16/215, Čt 17:00–18:40 A16/215, J. Slanina
aVLBC0321s/32: Út 14:00–15:40 A16/215, Pá 14:00–15:40 A16/213, E. Táborská
aVLBC0321s/33: Út 14:00–15:40 A16/215, Pá 14:00–15:40 A16/213, E. Táborská
aVLBC0321s/34: Út 8:00–9:40 A16/215, Čt 8:00–9:40 A16/215, H. Paulová
aVLBC0321s/35: Út 8:00–9:40 A16/215, Čt 8:00–9:40 A16/215, H. Paulová
aVLBC0321s/36: Út 10:00–11:40 A16/215, Čt 13:00–14:40 A16/215, J. Dostál, J. Slanina
aVLBC0321s/37: Po 16:00–17:40 A16/213, Čt 13:00–14:40 A16/215, J. Dostál
aVLBC0321s/38: Po 10:00–11:40 A16/215, Pá 12:00–13:40 A16/215, J. Tomandl
aVLBC0321s/39: Po 10:00–11:40 A16/215, Pá 12:00–13:40 A16/215, J. Tomandl
Předpoklady
aVLBI0222p Lékařská biologie II - př && aVLBF011p Biophysics - lecture
Omezení zápisu do předmětu
Předmět je určen pouze studentům mateřských oborů.
Mateřské obory/plány
Cíle předmětu
The aim of the course is to obtain knowledge on essential metabolic processes on the cellular level. Understanding these processes is a base for comprehension of metabolism on the tissue and organ level. Introductory lessons summarize the basic terms of chemistry needed for an understanding of body structure a physico-chemical processes occurring in it (chemical composition of the body, biologically important elements, water, electrolytes, non-electrolytes, osmotic pressure, acid-base, redox and precipitation reactions), the following lectures are focused on biochemical pathways in cells.
Výstupy z učení
At the end of the course, students will be competent to:
- understand the meaning of basic chemical terms (pH, osmolality, electrolyte, buffer, etc.) and apply this knowledge when describing the properties of body fluids.
- describe the role of macro/microbiogenic elements in the body.
- discuss the properties and function of enzymes
- describe basic catabolic and anabolic pathways of carbohydrates, lipids, and protein metabolism, and their relationships.
- understand the principles of energy production, utilization and deposition at the cellular level.
- explain the function of cell membranes and the principle of compartmentalization at the cellular level and the transport processes on the membrane.
- describe protein synthesis, starting with the replication and transcription, translation and post-translational modifications.
- understand the relationship between protein structure and function.
- explain the function of hemoglobin in oxygen transport and maintaining acid-base balance.
- discuss the principles of some diseases at the molecular level.
Osnova
  • Electrolytes, osmolality, tonicity, oncotic pressure, osmolal gap.
  • Acid-base reactions, pH of body fluids.
  • Buffers, Henderson-Hasselbalch equation.
  • Biochemically important organic compounds I (alcohols, aldehydes).
  • Biochemically important organic compounds II (carboxylic acids and derivatives).
  • Bioenergetics, Gibbs energy, ATP, redox reactions.
  • Enzymes, kinetics, saturation curve, inhibition.
  • Cofactors of enzymes, relation to vitamins.
  • Citrate cycle, respiratory chain.
  • Saccharides, structures, nutrition, digestion. Transport of glucose into cells. Glycolysis.
  • Metabolism of glycogen. Metabolism of fructose and galactose.
  • Surfactants (types, physiological roles). Lipids (structures).
  • Biological membranes. Membrane transport.
  • Lipids in nutrition, digestion. Catabolism of fatty acids, ketone bodies.
  • Desaturation of fatty acids. Cholesterol.
  • Metabolism of bile acids, eicosanoids, phospholipids.
  • Lipophilic vitamins, ROS. Lipid peroxidation.
  • Amino acids, proteins, structure, properties.
  • Hemoglobin, types, function, abnormal types.
  • Digestion of proteins, general features of amino acid metabolism, synthesis of urea.
  • Metabolism of amino acids I (catabolism, synthesis of non-essential AA, congenital disorders).
  • Metabolism of amino acids II (conversions to special products, heme).
  • Structure of bases, nucleosides, nucleotides, roles of nucleotides. Metabolism of purine and pyrimidine bases I.
  • Metabolism of purine and pyrimidine bases II.
  • DNA, RNA structure, replication, transcription.
  • Protein synthesis. Post-translation modification, collagen synthesis.
Literatura
    povinná literatura
  • Seminar texts available in Information system
  • RODWELL, Victor W., David A. BENDER, Kathleen M. BOTHAM, Peter J. KENNELLY a P. Anthony WEIL. Harper's illustrated biochemistry. Thirty-first edition. New York: McGraw-Hill, 2018, x, 789. ISBN 9781260288421. info
    doporučená literatura
  • LIEBERMAN, Michael a Alisa PEET. Marks' basic medical biochemistry : a clinical approach. Illustrated by Matthew Chansky. 5th edition. Philadelphia: Wolters Kluwer, 2018, xii, 1051. ISBN 9781496387721. info
  • KOOLMAN, Jan a Klaus-Heinrich ROEHM. Color Atlas of Biochemistry. 3rd ed. Georg Thieme Verlag, 2013. ISBN 978-3-13-100373-7. info
  • VASUDEVAN, D. M., S. SREEKUMARI a Kannan VAIDYANATHAN. Textbook of biochemistry for medical students. Eighth edition. New Delhi: Jaypee The Health Sciences Publisher, 2016, xvi, 718. ISBN 9789385999741. info
Výukové metody
Seminar. The course is based on group discussion on the given topics. The outlines of the discussion are in the recommended textbook. Complementary materials are available in section Study materials in IS MUNI.
Metody hodnocení
Course-unit credit. Conditions for giving the course-unit credit (both conditions should be met):
  • Full attendance in lessons. All absences should be justified and then made up.
  • At least 70% success rate from partial revision tests or 50% success rate in credit test, the resit credit test can be taken only once.
    The detailed conditions are posted in Information System (Study materials – Course-related instructions).
    • Vyučovací jazyk
    Angličtina
    Další komentáře
    Předmět je vyučován každoročně.
    Nachází se v prerekvizitách jiných předmětů
    Předmět je zařazen také v obdobích podzim 2016, podzim 2017, podzim 2018, podzim 2019, podzim 2020, podzim 2021, podzim 2023, podzim 2024.