LF:VSBC0221p Biochemistry I -lect. - Course Information
VSBC0221p Biochemistry I - lecture
Faculty of MedicineSpring 2011
- Extent and Intensity
- 2/0. 4 credit(s). Recommended Type of Completion: zk (examination). Other types of completion: k (colloquium).
- Teacher(s)
- doc. RNDr. Jiří Dostál, CSc. (lecturer)
prof. MUDr. Vladimír Palyza, CSc. (lecturer)
RNDr. Hana Paulová, CSc. (lecturer)
Mgr. Jiří Slanina, Ph.D. (lecturer)
prof. RNDr. Eva Táborská, CSc. (lecturer)
doc. RNDr. Josef Tomandl, Ph.D. (lecturer)
PharmDr. Lenka Adámková, Ph.D. (assistant)
RNDr. Hana Bochořáková (assistant)
Ing. Martina Čarnecká, Ph.D. (assistant)
MUDr. Zdeňka Čermáková, Ph.D. (assistant)
Mgr. Miroslav Dvořák, Ph.D. (assistant)
MUDr. Michaela Králíková, Ph.D. (assistant)
Mgr. Milena Matejovičová, Ph.D. (assistant)
Ing. Jitka Melounová, Ph.D. (assistant)
Lenka Nerudová (assistant)
PharmDr. Kristýna Šebrlová, Ph.D. (assistant)
Mgr. Marie Tomandlová, Ph.D. (assistant) - Guaranteed by
- prof. RNDr. Eva Táborská, CSc.
Department of Biochemistry – Theoretical Departments – Faculty of Medicine - Timetable
- Thu 10:30–12:20 B22/116 aula
- Timetable of Seminar Groups:
VSBC0221p/30: Wed 13:00–14:50 B11/234 - Prerequisites (in Czech)
- VSLC011s Med.Chem.-seminary && VSLC011c Medical Chemistry -p && ZC011 Handling chemical substances
- Course Enrolment Limitations
- The course is only offered to the students of the study fields the course is directly associated with.
- fields of study / plans the course is directly associated with
- Nutritive therapist (programme LF, B-SZ)
- General Medicine (eng.) (programme LF, M-VL)
- General Medicine (programme LF, M-VL) (2)
- Course objectives
- The aim of the course is to obtain knowledge on essential metabolic processes on the cell level. The graduate is acquainted with properties and function of enzymes, is oriented in catabolic and anabolic pathways of metabolism of saccharides, lipids and proteins and their consequences.Understands the principles of cell bioenegetics.Become familiar with the funcion of cell membranes, principle of cell compartmentation and membrane transport.Has knowledge on proteosynthesis including processes replication,transcription, translation and posttranslantion modifications.Understands the relation between the structure and function of proteins. Is acquinted with function of hemoglobine in oxygen transport.Molecular bases of some diseases are introduced. The course provides the essential knowledge for future understanding of metabolism on organe and inter-organe level and its disturbances.
- Syllabus
- Membrane structure, the assembly and recycling of membranes. Specialized structures of plasma membrane – lipid rafts, caveols, tight junctions. membrane transport. Enzymes. Characteristic features of biocatalysis, enzyme structure and function, nomenclature and classification of enzymes. Enzyme cofactors, review of structures and functions. Mechanisms of enzyme action. Kinetics of enzyme catalyzed reactions. Assays of enzyme activity, the conditions used. Factors affecting catalytic activity of enzymes, types of enzyme inhibition. Metabolism: basic concepts and design. Biological oxidations, generation of high-energy compounds. Saccharide metabolism: the glycolytic pathway and aerobic decarboxylation of pyruvate. Gluconeogenesis. Glycogen biosynthesis and breakdown. The pentose phosphate pathway. The glucuronate pathway. Interconversions of monosaccharides and of their derivatives. Protein and amino acid metabolism. The common reactions in amino acid degradation. The ureosynthetic cycle. Metabolic breakdown of individual amino acids. Biosynthesis and breakdown of fatty acids, ketogenesis. Synthesis of triacylglycerols. Metabolism of phospholipids and glycolipids. Synthesis of eicosanoids. Biosynthesis and transformations of cholesterol, biosynthesis of bile acids. Interrelationships among the major pathways involved in energy metabolism. The citric acid cycle. Synthesis of haem. Mitochondria. Oxidative phosphorylation - mitochondrial electron transport chain, synthesis of ATP. Structure of haemoglobin, structure-function relationships (the oxygen saturation curve, inducement of haemoglobin saturation and oxygen transport. Bohr effect. Normal haemoglobin types in blood, haemoglobin concentration. Other forms (glycohaemoglobin, methaemoglobin, carboxyhaemoglobin) and abnormal haemoglobins. Biosynthesis and catabolism of purine and pyrimidine nucleotides. Chromatin, DNA replication. DNA transcription. Regulation of gene expression. Protein synthesis and post-translational processing.
- Literature
- required literature
- LEDVINA, Miroslav, Alena STOKLASOVÁ and Jaroslav CERMAN. Biochemie pro studující medicíny, I. a II. díl. Druhé vydání. Praha: Karolinum, 2009, 546 pp. ISBN 978-80-246-1414-4. info
- recommended literature
- HOLEČEK, Milan. Regulace metabolizmu cukrů, tuků, bílkovin a aminokyselin. 1st ed. Praha: Grada Publishing, 2006, 286 pp. učebnice. ISBN 80-247-1562-7. info
- HARVEY, Richard A. and Denise R. FERRIER. Biochemistry. 5th edition. Baltimore: Wolters Kluver, Lippincott Williams & Wilkins, 2011. International Edition. ISBN 978-1-60913-998-8. info
- Teaching methods
- Teaching form are lectures. Supplementary subjects are seminars VSBC021s
- Assessment methods
- Student must have course-unit credit of seminar in the day of exam. Examination has writen and oral part. Writen part has 25 questions and is solved on computers in computer room of Department of Biochemistry. The second part is oral.Examination questions and other instructions you will find in the section Study materials of the course.
- Language of instruction
- Czech
- Further comments (probably available only in Czech)
- Information on completion of the course: zkoušku lze konat až po absolvování zkoušky z Lékařské chemie
The course is taught annually.
Information on course enrolment limitations: Přihlášení ke zkoušce je podmíněno vykonáním zkoušky z Lékařské chemie. - Listed among pre-requisites of other courses
- BVTO0311c Medical toxicology - laboratory course
BVBC0221p||VSBC0221p&&BVEK011p - BVTO0311p Medical toxicology - lecture
BVBC0221p||VSBC0221p&&BVEK011p - VLIM051c Immunology - practice
(VLBC0422p ||VSBC0221p) && (VSFY0422p || VLFY0422p) - VLIM051p Immunology - lecture
(VLBC0422p ||VSBC0221p) && (VSFY0422p || VLFY0422p)
- BVTO0311c Medical toxicology - laboratory course
- Teacher's information
- http://www.med.muni.cz/toCP1250.cs/biochem/vyuka.html
- Enrolment Statistics (Spring 2011, recent)
- Permalink: https://is.muni.cz/course/med/spring2011/VSBC0221p