AMOLp Introduction into molecular biology and genetics - lecture

Faculty of Medicine
spring 2021
Extent and Intensity
2/0/0. 3 credit(s). Type of Completion: zk (examination).
Teacher(s)
Ing. Lívia Eiselleová, Ph.D. (lecturer)
Mgr. Kateřina Cetkovská, Ph.D. (lecturer)
Mgr. Kateřina Francová, Ph.D. (lecturer)
MUDr. Martin Pešl, Ph.D. (lecturer)
Mgr. Vladimír Rotrekl, Ph.D. (lecturer)
prof. RNDr. Ondřej Slabý, Ph.D. (lecturer)
prof. MUDr. David Šmajs, Ph.D. (lecturer)
Mgr. Stjepan Uldrijan, CSc. (lecturer)
Mgr. Ondřej Vymazal, Ph.D. (seminar tutor)
Jana Růžičková (assistant)
Guaranteed by
prof. MUDr. David Šmajs, Ph.D.
Department of Biology – Theoretical Departments – Faculty of Medicine
Contact Person: Ing. Lívia Eiselleová, Ph.D.
Supplier department: Department of Biology – Theoretical Departments – Faculty of Medicine
Timetable
Tue 2. 3. 13:00–14:50 B11/334, Tue 9. 3. 13:00–14:50 B11/334, Tue 16. 3. 13:00–14:50 B11/334, Tue 23. 3. 13:00–14:50 B11/334, Tue 30. 3. 13:00–14:50 B11/334, Tue 6. 4. 13:00–14:50 B11/334, Tue 13. 4. 13:00–14:50 B11/334, Tue 20. 4. 13:00–14:50 B11/334, Tue 27. 4. 13:00–14:50 B11/334, Tue 4. 5. 13:00–14:50 B11/334, Tue 11. 5. 13:00–14:50 B11/334, Tue 18. 5. 13:00–14:50 B11/334, Tue 25. 5. 13:00–14:50 B11/334, Tue 1. 6. 13:00–14:50 B11/334, Tue 8. 6. 13:00–14:50 B11/334
Prerequisites
(! VSBI0222p Biology II-lect. ) && (! VLBI0222p Biology II-lect. ) && (! ZLBI0222p Biology II-lect. ) && (! PřF:Bi1700 Cell Biology )
Knowledge high-school biology on the level of Overview of High School Biology (https://is.muni.cz/auth/do/med/el/overview/overview_CZ.qwarp) or similar.
Course Enrolment Limitations
The course is also offered to the students of the fields other than those the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
The main objectives of the course are:
- understanding the elementary cellular processes and the principle of intercellular communication
- understanding the principle of developing bacterial, viral and genetically determined diseases
- understanding the mechanisms of cancer development
- acquaintance with the basics of genomics, gene therapy and tissue engineering in current medicine
Learning outcomes
After completing the course, the student will be able to:
- describe composition and architecture of cells, explain elementary processes taking place in cells and the human body (gene expression, intercellular communication, cell differentiation, cell division, cell death) and their purposes
- explain the difference between healthy and pathologically-working cell, and express the basic coherence between malfunctioning cellular processes and development of diseases
- explain the general mechanism of pathogenesis in bacterial and viral diseases
- explain the principles of heredity, explain the general mechanism of pathogenesis of gene mutations and chromosome aberrations in humans, and illustrate it with examples
- explain the nature of cancers with regard to deregulation of cell division, DNA repair and cell death
- understand basic approaches of molecular diagnostics
- describe basic strategies of cell and gene therapy and genetic engineering
Syllabus
  • Introduction. Bacteria and viruses
  • Architecture and function of eukaryotic cells.
  • Proteins and nucleic acids, DNA replication
  • From genes to proteins - the expression of genetic information
  • Cellular communication. Cell differentiation
  • The cell cycle and its regulation. Cell death
  • Malignant transformation of cells
  • Mitosis and meiosis
  • Principles of heredity I - the karyotype and chromosomal aberrations
  • Principles of heredity II - genes and gene mutations
  • Multifactorial inheritance. Molecular diagnostics
  • Stem cells and strategies of molecular therapy
  • The human genome and gene engineering. Gene therapy
Literature
    required literature
  • ALBERTS, Bruce. Základy buněčné biologie : úvod do molekulární biologie buňky. Translated by Arnošt Kotyk. 2. vyd. Ústí nad Labem: Espero Publishing, 2004, xxvi, 630. ISBN 8090290620. info
    not specified
  • PRITCHARD, D. J. and Bruce R. KORF. Základy lékařské genetiky. první české vydání. Praha: Galén, 2007, 182 stran. ISBN 9788072624492. info
Teaching methods
two-hour lecture per week
Assessment methods
The course is completed with a written exam test containing 60 questions. In one ne half of the test questions student choses between yes/no (without negative marking). The other half of the test questions offers 4 possible answers, where 1 to all answers can be correct (negative marking applies for incorrect answers). To pass the exam, 30 points are needed (out of 60). The test is based on knowledge of all topics from lectures and practices.
Succesfull passing of the courses's practice is required for attending the exam.
Attendance at the lectures is optional.
Language of instruction
Czech
Further comments (probably available only in Czech)
The course is taught annually.
Information on the extent and intensity of the course: 30.
Information on course enrolment limitations: Student nesmí mít absolvovaný ani současně zapsaný předmět Biologie II na LF, ani předmět Bunečná biologie Bi1700 na PřF.
Teacher's information
https://is.muni.cz/auth/el/1411/jaro2020/AMOLp/index.qwarp
The course is also listed under the following terms Spring 2008, Spring 2009, Spring 2010, Spring 2011, Spring 2012, Spring 2013, Spring 2014, Spring 2015, Spring 2016, Spring 2017, Spring 2018, spring 2019, spring 2020, spring 2022, spring 2023, spring 2024, spring 2025.
  • Enrolment Statistics (spring 2021, recent)
  • Permalink: https://is.muni.cz/course/med/spring2021/AMOLp