BVTO0311p Medical toxicology - lecture

Faculty of Medicine
Autumn 2008
Extent and Intensity
1/0/0. 2 credit(s). Type of Completion: zk (examination).
Teacher(s)
prof. MUDr. Drahoslava Hrubá, CSc. (lecturer)
Guaranteed by
prof. MUDr. Drahoslava Hrubá, CSc.
Department of Preventive Medicine – Theoretical Departments – Faculty of Medicine
Contact Person: MVDr. Halina Matějová
Timetable
Tue 7:30–9:00 N02113a
Prerequisites (in Czech)
VSBC0221p Biochemistry I -lect.
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
Understanding of the fundamental knowledge of basic toxicology. Routes of exposure, intake, uptake; metabolism, genetic polymorphism influencing the sussceptibility to chemical exposure; excretion. The outcomes of exposure to chemicals, the methods for their detection. Obtaining the basic knowledge about special toxicology, with the concern about chemical contaminants of food chains. Training the skills in methods used in basic and special toxicology, including the tests of genotoxicity.
Syllabus
  • Environmental chemical contaminants - problems, world catastrophes. Intake, uptake in toxicology. Anti-chemical defense systems in the human body. Metabolism of chemicals, the role of microsomal enzymes. Genetic determination of the differences in the metabolism of xenobiotics, the effects on human sussceptibility to chemicals. The methods of experimental studies in toxicology, interpretation of their results for the human exposure. Polychlorinated hydrocarbons: DDT, PCB, PCDD, PCDF: toxicology, control. Heavy metals: Hg, Pb, Cd, As, Cr: toxicology, control. Polycyclic aromatic hydrocarbons and their nitroso-derivates: toxicology, control. Pesticides, natural pesticides.
Literature
  • F.C. LU: Basic toxicology. Taylor, Francis (Ed), Washington, 1996. ISBN 1-56032-380-9
  • Ph.S.Guzelian (Ed): Similarities and differences between children and adults. ILSI Press, Washington, 1992. ISBN 0-944398-07-3
  • Manuál prevence v lékařské praxi. Edited by Kamil Provazník - Miroslav Cikrt - Lumír Komárek. Vyd. 1. Praha: Státní zdravotní ústav, 2000, 158 s. ISBN 8070711612. info
  • KOTULÁN, Jaroslav and Drahoslava HRUBÁ. Preventivní lékařství :učební text pro lékařské fakulty. Brno: Masarykova univerzita, 1993, 207 s. ISBN 80-210-0563-7. info
  • KOTULÁN, Jaroslav, Drahoslava HRUBÁ and Vladimír BENCKO. Preventivní lékařství :učební text pro lékařské fakulty. Brno: Masarykova univerzita, 1993, 285 s. ISBN 80-210-0336-7. info
Assessment methods
Written tests, oral exam
Language of instruction
Czech
Follow-Up Courses
Listed among pre-requisites of other courses
The course is also listed under the following terms Autumn 2009, Autumn 2010, Autumn 2011, Autumn 2012, Autumn 2013, Autumn 2014, Autumn 2015, Autumn 2016, Autumn 2017, autumn 2018, autumn 2019, autumn 2020, autumn 2021, autumn 2022, autumn 2023, autumn 2024.
  • Enrolment Statistics (Autumn 2008, recent)
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