VLKB091 Clinical chemistry

Faculty of Medicine
Autumn 2008
Extent and Intensity
0/2/0. 1 credit(s). Type of Completion: k (colloquium).
Teacher(s)
doc. MUDr. Milan Dastych, CSc., MBA (lecturer)
MUDr. Michaela Králíková, Ph.D. (lecturer)
prof. MUDr. Vladimír Palyza, CSc. (lecturer)
doc. MUDr. Jaromír Sláma, CSc. (lecturer)
prof. MUDr. Vladimír Soška, CSc. (lecturer)
prof. RNDr. Eva Táborská, CSc. (lecturer)
Lenka Nerudová (assistant)
Mgr. Jiří Slanina, Ph.D. (assistant)
doc. RNDr. Josef Tomandl, Ph.D. (assistant)
Guaranteed by
prof. MUDr. Vladimír Palyza, CSc.
Department of Biochemistry – Theoretical Departments – Faculty of Medicine
Contact Person: Lenka Nerudová
Timetable
Mon 29. 9. to Fri 5. 12. Mon 14:45–17:25 KOM 257
Prerequisites (in Czech)
( VLFA0822p Pharmacology II - L || VLFA0722p Pharmacology - L ) && VLVL7X61c Internal medicine part 1
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Syllabus
  • Analytical sources of variation, accuracy and precision. Diagnostic accuracy, sensitivity, specificity, and efficiency of diagnostic tests. Reference ranges, decision values. Collection and processing of specimens, special requirements, general safety rules.
  • Assessment and monitoring of nutritional status. Blood plasma proteins. Acute-phase reactants. Principles of nutritional support, enteral and parenteral nutrition. Dietary constituents providing a sufficient energy intake.
  • Energy output, nitrogen balance. Indications for nutritional support. Oxygen, transport and metabolism, tissue hypoxia.
  • Disorders of lipid and lipoprotein metabolism.
  • Ischemic heart disease, congestive cardiac failure. Potassium and magnesium homeostasis.
  • Iron and essential microelements metabolism.
  • Disturbances of water and sodium balance. Plasma and urine osmolality. Plasma electrolytes in acid-base disorders.
  • Assessment of acid-base balance. Investigating an acid-base status, indications for blood acid-base and oxygen measurements, interpretation of results.
  • Laboratory evaluation of kidney function. Biochemical monitoring of acute and chronic renal failure, and of patients receiving haemodialysis. Urine sediment.
  • Investigation of liver and biliary tract diseases. Signs of the liver injury, differentiating of hyperbilirubinaemias, syndrome of biliary obstruction.
  • Clinical biochemistry of the GIT. Gastric acid secretion, maldigestion and malabsorption, assessment of pancreatic function.
  • Disorders of saccharide metabolism, diabetes mellitus.
  • Calcium and phosphate metabolism. Biochemical markers of bone metabolism (in the assessment of osteoporosis).
  • Uric acid, hyperuricaemia. Renal tract stones.
  • Laboratory assessment of thyroid and adrenal functions.
  • Tumour markers. Biological causes of variation of test results, effects of drugs on chemical tests.
Literature
  • RACEK, Jaroslav. Klinická biochemie (Clinical chemistry). 1st ed. Praha: Galén, 1999, 316 pp. ISBN 80-7262-023-1. info
  • SCHNEIDERKA, Petr. Vybrané kapitoly z klinické biochemie (Selected Chapters from Clinical Chemistry). 1st ed. Praha: Karolinum, 1998, 120 pp. ISBN 80-7184-505-1. info
  • MASOPUST, Jaroslav. Klinická biochemie. Požadování a hodnocení biochemických vyšetření. (Clinical chemistry.). 1st ed. Praha: Karolinum, 1998, 832 pp. část I. a část II. ISBN 80-7184-649-3. info
  • LAKER, M.F. Clinical Biochemistry for Medical Students. 1st ed. London: Saunders Co. Ltd., 1996, 357 pp. ISBN 0-7020-1690-X. info
  • WHITBY, L.G., A.F. SMITH, G.J. BECKETT and S.W. WALKER. Lecture Notes on Clinical Biochemistry. 5th ed. Oxford: Blackwell Scientific Publications, 1993, 438 pp. ISBN 0-632-03687-7. info
Language of instruction
Czech
Further comments (probably available only in Czech)
Study Materials
The course is taught annually.
Information on course enrolment limitations: kromě studentů LF maximálně 3 studenti MU v jednom běhu
Listed among pre-requisites of other courses

Zobrazit další předměty

The course is also listed under the following terms Autumn 2000, Autumn 2001, Autumn 2002, Autumn 2003, Autumn 2004, Autumn 2005, Autumn 2006, Spring 2007, Autumn 2007, Spring 2008, Spring 2009, Autumn 2009, Autumn 2010, Autumn 2011, Autumn 2012, Autumn 2013, Autumn 2014, Autumn 2015, Autumn 2016, Autumn 2017, autumn 2018, autumn 2019, autumn 2020, autumn 2021, autumn 2022, autumn 2023, autumn 2024.
  • Enrolment Statistics (Autumn 2008, recent)
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