C9531 Structure of biomacromolecules

Faculty of Science
Autumn 2008
Extent and Intensity
0/1/0. 1 credit(s) (fasci plus compl plus > 4). Type of Completion: z (credit).
Teacher(s)
prof. Mgr. Lukáš Žídek, Ph.D. (seminar tutor)
Guaranteed by
prof. Mgr. Lukáš Žídek, Ph.D.
National Centre for Biomolecular Research – Faculty of Science
Contact Person: prof. Mgr. Lukáš Žídek, Ph.D.
Timetable
Wed 17:00–17:50 F01B1/709, Wed 18:00–18:50 F01B1/709
  • Timetable of Seminar Groups:
C9531/C9530_17: No timetable has been entered into IS. L. Žídek
C9531/C9530_18: No timetable has been entered into IS. L. Žídek
Prerequisites
NOW( c9530 Structure of biomacromolecules )
The seminar is offered to students attending course C9530 (Structure of biomacromolecules).
Course Enrolment Limitations
The course is also offered to the students of the fields other than those the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
The aim of the seminar is to offer the chance to practice the knowledge acquired in course C9530 (Structure of biomacromolecules) and to prepare students for the exam of the course C9530. Therefore, students attending the course should gain practical experience with solving problems related to understanding structure of biomacromolecules and methods of structure determination.
Syllabus
  • 1. Torsion angle determination, work with protein models. 2. Work with ucleic acid models, determination of pseudorotation. 3. Program Rasmol, demonstration of molecular mechanics. 4. Nucleic acid sequencing, designing site-directed mutagenesis. 5. Peptide sequencing using mass spectrometry. 6. IR and CD protein spectra interpretation. 7. Sequential assignment of protein NMR spectra. 8. Sequential assignment of nucleic acid NMR spectra. 9. X-ray diffraction - resolution, phase problem, refinement. 10. Work with databases of sequences and structures.
Literature
  • LESK, Arthur M. Introduction to protein architecture : the structural biology of proteins. Oxford: Oxford University Press, 2001, xii, 347. ISBN 0198504748. info
  • CAVANAGH, John. Protein NMR spectroscopy : principles and practice. 2nd ed. Amsterdam: Elsevier, 2007, xxv, 885. ISBN 9780121644918. info
Assessment methods
Students are required to solve at least 60% problems in each of oral test during semester. Excellent perforamce will be taken into account during the C9530 examination.
Language of instruction
Czech
Further Comments
The course is taught annually.
Teacher's information
http://www.ncbr.chemi.muni.cz/~lzidek/C9531/C9531.html
The course is also listed under the following terms Autumn 2007 - for the purpose of the accreditation, Autumn 2010 - only for the accreditation, Autumn 2002, Autumn 2003, Autumn 2004, Autumn 2005, Autumn 2006, Autumn 2007, Autumn 2009, Autumn 2010, Autumn 2011, Autumn 2011 - acreditation, Autumn 2012, Autumn 2013, Autumn 2014, Autumn 2015, Autumn 2016, autumn 2017, Autumn 2018, Autumn 2019, Autumn 2020, autumn 2021, Autumn 2022, Autumn 2023, Autumn 2024.
  • Enrolment Statistics (Autumn 2008, recent)
  • Permalink: https://is.muni.cz/course/sci/autumn2008/C9531