Bi4020 Molecular biology

Faculty of Science
Spring 2009
Extent and Intensity
3/0/0. 3 credit(s) (fasci plus compl plus > 4). Type of Completion: zk (examination).
Teacher(s)
prof. RNDr. Jiří Doškař, CSc. (lecturer)
Guaranteed by
prof. RNDr. Jiří Doškař, CSc.
Department of Experimental Biology – Biology Section – Faculty of Science
Contact Person: prof. RNDr. Jiří Doškař, CSc.
Timetable
Wed 8:00–10:50 aula_Vinařská
Prerequisites
! Bi4010 Essential molecular biology
Basic knowledge of general zoology and botany, microbiology, genetics, physiology, organic chemistry and biochemistry.
Course Enrolment Limitations
The course is also offered to the students of the fields other than those the course is directly associated with.
fields of study / plans the course is directly associated with
there are 20 fields of study the course is directly associated with, display
Course objectives
This lecture is conceived as an introduction into molecular biology. It gives the explanation of processes on molecular level in relation to the basic functions of living systems (procaryotic as well as eucaryotic organisms and viruses). On the whole, the general molecular processes occuring in living systems are emphasized in this lecture with respect to the specificities characteristic of the main groups of living systems (bacteria, archea, plants, animals and viruses)
Syllabus
  • History of molecular biology
  • Nucleic acids (primary, secondary and tertiary structure of DNA and RNA, different conformations of DNA and their significance in biological systems)
  • Interactions of proteins with DNA
  • Genetic information and the genetic code. Molecular structure of procaryotic and eucaryotic genome. Replication of procaryotic and eucaryotic genome
  • Transcription of procaryotic and eucaryotic genome
  • Postranscriptional modification and processing of RNA, especially in eucaryotes
  • Mechanisms of splicing and selfsplicing
  • Translation of procaryotic and eucaryotic mRNA
  • Posttranslational processing
  • Regulation of gene expression in procaryotes and eucaryotes
  • Signal pathways in mammal cells and their relation to the activation of transcription factors. Molecular basis of acquired immunity
  • Molecular basis of cancerogenesis (oncogenes, antioncogenes
  • Molecular mechanisms of mutagenesis and recombination
  • Transposons
  • Repair mechanisms of damaged DNA
  • Basic principles of gene engineering
Literature
  • ROSYPAL, Stanislav. Úvod do molekulární biologie (Introduction to molecular biology). Čtvrté inovované vydání. Brno: Prof. RNDr. Stanislav Rosypal, DrSc., Brno, 2006, 290 pp. Díl I. Molekulární biologie prokaryotické buňky. ISBN 80-902562-5-2. URL info
  • ROSYPAL, Stanislav. Úvod do molekulární biologie. Třetí inovované vydání. Brno, 1999, 300 pp. Díl II. Molekulární biologie eukaryot. ISBN 80-902562-1-X. URL info
  • ROSYPAL, Stanislav. Úvod do molekulární biologie. Třetí inovované vydání. Brno, 2000, 300 pp. Díl III. Molekulární biologie virů. ISBN 80-902562-2-8. URL info
  • ROSYPAL, Stanislav, Jiří DOŠKAŘ, Karel PETRZIK and Vladislava RŮŽIČKOVÁ. Úvod do molekulární biologie IV. Molekulární biologie rostlinných virů, Priony, Molekulkární evoluce, Vznik života, Metody molekulární biologie, Genové inženýrství (Introduction to molecular biology IV.). Třetí inovované vydání. Brno: Rosypal S., Grafex, 2002, 300 pp. Díl čtvrtý. ISBN 80-902562-4-4. info
  • ROSYPAL, Stanislav, Jiří DOŠKAŘ, Roman PANTŮČEK, Jana KAILEROVÁ, Jiřina RELICHOVÁ, Vladislava RŮŽIČKOVÁ, Jan ŠMARDA, Jan ŠMARDA and Jiří ŠTĚPÁN. TERMINOLOGIE MOLEKULÁRNÍ BIOLOGIE. České odborné termíny, definice a anglické ekvivalenty (Terminology of molecular biology). První vydání. Brno: Vydavatel Prof. RNDr. Stanislav Rosypal, DrSc. Vodova 80, 612 00 Brno, 2001, 300 pp. ISBN 80-902562-3-6. URL info
  • ALBERTS, Bruce. Základy buněčné biologie : úvod do molekulární biologie buňky a : Essential cell biology (Orig.). Ústí nad Labem: Espero Publishing, xxvi, 630,. info
Assessment methods
written test
Language of instruction
Czech
Follow-Up Courses
Further comments (probably available only in Czech)
Study Materials
The course is taught annually.
Listed among pre-requisites of other courses

Zobrazit další předměty

The course is also listed under the following terms Spring 2008 - for the purpose of the accreditation, Spring 2011 - only for the accreditation, Spring 2003, Spring 2004, Spring 2005, Spring 2006, Spring 2007, Spring 2008, Spring 2010, Spring 2011, Spring 2012, spring 2012 - acreditation, Spring 2013, Spring 2014, Spring 2015, Spring 2016, Spring 2017, spring 2018, Spring 2019, Spring 2020, Spring 2021, Spring 2022, Spring 2023, Spring 2024, Spring 2025.
  • Enrolment Statistics (Spring 2009, recent)
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