Bi4020 Molecular biology

Faculty of Science
Spring 2017
Extent and Intensity
3/0/0. 3 credit(s) (fasci plus compl plus > 4). Type of Completion: zk (examination).
Teacher(s)
prof. RNDr. Jiří Doškař, CSc. (lecturer)
Guaranteed by
prof. RNDr. Jiří Doškař, CSc.
Department of Experimental Biology – Biology Section – Faculty of Science
Contact Person: prof. RNDr. Jiří Doškař, CSc.
Supplier department: Department of Experimental Biology – Biology Section – Faculty of Science
Timetable
Mon 20. 2. to Mon 22. 5. Tue 13:00–15:50 B11/132
Prerequisites
! Bi4010 Essential molecular biology
Basic knowledge of general zoology and botany, microbiology, genetics, physiology, organic chemistry and biochemistry.
Course Enrolment Limitations
The course is also offered to the students of the fields other than those the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
At the end of the course students should be able to understand and explain basic principles of molecular biology and genetics on molecular level and their basic phenomena - the structure, replication, expression and changes of genes.
Syllabus
  • History of molecular biology
  • Nucleic acids (primary, secondary and tertiary structure of DNA and RNA, different conformations of DNA and their significance in biological systems)
  • Interactions of proteins with DNA
  • Genetic information and the genetic code. Molecular structure of procaryotic and eucaryotic genome. Replication of procaryotic and eucaryotic genome
  • Transcription of prokaryotic and euckryotic genome
  • Posttranscriptional modification and processing of RNA, especially in eukaryotes
  • Mechanisms of splicing and self-splicing
  • Translation of prokaryotic and eukaryotic mRNA
  • Posttranslational processing
  • Regulation of gene expression in prokaryotes and eukaryotes
  • Signal pathways in mammal cells and their relation to the activation of transcription factors. Molecular basis of acquired immunity
  • Molecular basis of cancerogenesis (oncogenes, antioncogenes
  • Molecular mechanisms of mutagenesis and recombination
  • Transposons
  • Repair mechanisms of damaged DNA
  • Basic principles of gene engineering
Literature
    recommended literature
  • ROSYPAL, Stanislav. Úvod do molekulární biologie (Introduction to molecular biology). Čtvrté inovované vydání. Brno: Prof. RNDr. Stanislav Rosypal, DrSc., Brno, 2006, 290 pp. Díl I. Molekulární biologie prokaryotické buňky. ISBN 80-902562-5-2. URL info
  • ROSYPAL, Stanislav. Úvod do molekulární biologie. Třetí inovované vydání. Brno, 1999, 300 pp. Díl II. Molekulární biologie eukaryot. ISBN 80-902562-1-X. URL info
  • ROSYPAL, Stanislav. Úvod do molekulární biologie. Třetí inovované vydání. Brno, 2000, 300 pp. Díl III. Molekulární biologie virů. ISBN 80-902562-2-8. URL info
  • ROSYPAL, Stanislav, Jiří DOŠKAŘ, Karel PETRZIK and Vladislava RŮŽIČKOVÁ. Úvod do molekulární biologie IV. Molekulární biologie rostlinných virů, Priony, Molekulkární evoluce, Vznik života, Metody molekulární biologie, Genové inženýrství (Introduction to molecular biology IV.). Třetí inovované vydání. Brno: Rosypal S., Grafex, 2002, 300 pp. Díl čtvrtý. ISBN 80-902562-4-4. info
  • ROSYPAL, Stanislav, Jiří DOŠKAŘ, Roman PANTŮČEK, Jana KAILEROVÁ, Jiřina RELICHOVÁ, Vladislava RŮŽIČKOVÁ, Jan ŠMARDA, Jan ŠMARDA and Jiří ŠTĚPÁN. TERMINOLOGIE MOLEKULÁRNÍ BIOLOGIE. České odborné termíny, definice a anglické ekvivalenty (Terminology of molecular biology). První vydání. Brno: Vydavatel Prof. RNDr. Stanislav Rosypal, DrSc. Vodova 80, 612 00 Brno, 2001, 300 pp. ISBN 80-902562-3-6. URL info
  • ALBERTS, Bruce. Základy buněčné biologie : úvod do molekulární biologie buňky a : Essential cell biology (Orig.). Ústí nad Labem: Espero Publishing, xxvi, 630,. info
  • CLARK, David P. Molecular biology. Amsterdam: Elsevier, 2005, xviii, 784. ISBN 0121755517. info
  • ALBERTS, Bruce. Molecular biology of the cell. 5th ed. New York, N.Y.: Garland science, 2008, xxxiii, 12. ISBN 9780815341062. info
  • SNUSTAD, D. Peter, Michael J. SIMMONS, Jiřina RELICHOVÁ, Jiří DOŠKAŘ, Jiří FAJKUS, Petr HOŘÍN, Aleš KNOLL, Petr KUGLÍK, Jan ŠMARDA, Jana ŠMARDOVÁ, Renata VESELSKÁ and Boris VYSKOT. Genetika (Principles of Genetics). 1st ed. Brno: Masarykova univerzita, 2009, 894 pp. Učebnice. ISBN 978-80-210-4852-2. URL info
Teaching methods
Lectures are based on power-point pictures, tables and texts elaborated accordindg to textbooks, monographs and scientific papers which are explained and complemented with teacher comments. All the presentations are available on IS MUNI.
Assessment methods
Visiting of the course is not obligatory. The exam is a written test in which students should answer 50 questions covering main topics of individual lectures. To pass the exam the students should answer 60% of the answers.
Language of instruction
Czech
Follow-Up Courses
Further comments (probably available only in Czech)
Study Materials
The course is taught annually.
Listed among pre-requisites of other courses

Zobrazit další předměty

The course is also listed under the following terms Spring 2008 - for the purpose of the accreditation, Spring 2011 - only for the accreditation, Spring 2003, Spring 2004, Spring 2005, Spring 2006, Spring 2007, Spring 2008, Spring 2009, Spring 2010, Spring 2011, Spring 2012, spring 2012 - acreditation, Spring 2013, Spring 2014, Spring 2015, Spring 2016, spring 2018, Spring 2019, Spring 2020, Spring 2021, Spring 2022, Spring 2023, Spring 2024, Spring 2025.
  • Enrolment Statistics (Spring 2017, recent)
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